UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  _____________

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 2 )*

                           RIGEL PHARMACEUTICALS, INC.
-----------------------------------------------------------------------------
                                (Name of Issuer)

                    COMMON STOCK, $0.001 PAR VALUE PER SHARE
-----------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   766559 10 8
-----------------------------------------------------------------------------
                                 (CUSIP Number)

                                    Copy to:

         Thomas S. Hodge                                 David Wilson
------------------------------------------------------------------------------
         Chief Operating Officer          Heller Ehrman White & McAuliffe, LLP
         Two Union Square                      701 Fifth Avenue, Suite 6100
         601 Union Street                            Seattle, WA  98104
         Seattle, WA  98101
         (206) 621-7200                                (206) 447-0900

                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                January 24, 2005
------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box
.

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).






                                  SCHEDULE 13D

------------------------------------------------------------------------------

 CUSIP No. 766559 10 8
------------------------------------------------------------------------------


------------------------------------------------------------------------------
1  Name of Reporting Persons. I.R.S.Identification Nos. of above persons 
   (entities only).

   FRAZIER HEALTHCARE II, L.P.
------------------------------------------------------------------------------
------------------------------------------------------------------------------
2  Check the Appropriate Box if a Member of a Group (See Instructions)

   (a)

   (b)
------------------------------------------------------------------------------
------------------------------------------------------------------------------

3  SEC Use Only
------------------------------------------------------------------------------
------------------------------------------------------------------------------

4  Source of Funds (See Instructions)


   00
------------------------------------------------------------------------------
------------------------------------------------------------------------------

5  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d)
   or 2(e)
------------------------------------------------------------------------------
------------------------------------------------------------------------------

6  Citizenship or Place of Organization


   Delaware
------------------------------------------------------------------------------
-------- ------ --------------------------------------------------------------

  Number of             7      Sole Voting Power
  Shares
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With
                        ------ -----------------------------------------------
                        ------ -----------------------------------------------

                        8      Shared Voting Power


                               0
                        ------ -----------------------------------------------

                        9      Sole Dispositive Power


                               0
                        ------ -----------------------------------------------

                        10     Shared Dispositive Power


                               0
----------------------- ------ -----------------------------------------------
                                       2



--------------- --------------------------------------------------------------

11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                0
--------------- --------------------------------------------------------------
--------------- --------------------------------------------------------------
12
                Check if the Aggregate Amount in Row (11) Excludes Certain
                Shares (See Instructions)
--------------- --------------------------------------------------------------
--------------- --------------------------------------------------------------
13
                Percent of Class Represented by Amount in Row (11)


                0%
--------------- ---------------------------------------------------------------
14
                Type of Reporting Person (See Instructions)
                OO

--------------- ---------------------------------------------------------------
                                       3



-------------------------------------------------------------------------------

 CUSIP No. 766559 10 8
-------------------------------------------------------------------------------


--------------- ---------------------------------------------------------------
1               Name of Reporting Persons.   I.R.S.Identification Nos. of above
                persons (entities only).

                FHM II, L.L.C.
--------------- ---------------------------------------------------------------
--------------- ---------------------------------------------------------------
2               Check the Appropriate Box if a Member of a Group 
                (See Instructions)

                (a)

                (b)
--------------- -------------------------------------------------------------
--------------- -----------------------------------------------------------

3               SEC Use Only
--------------- -------------------------------------------------------
--------------- -------------------------------------------------------------

4               Source of Funds (See Instructions)


                OO
--------------- --------------------------------------------------------------
--------------- -----------------------------------------------------------

5               Check if Disclosure of Legal Proceedings Is Required Pursuant
                to Items 2(d) or 2(e)
--------------- -------------------------------------------------------------
--------------- -------------------------------------------------------------

6               Citizenship or Place of Organization


                Delaware
--------------- -------------------------------------------------------------
----------------------- ------ ----------------------------------------------

  Number of             7      Sole Voting Power
  Shares
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With
                        ------ --------------------------------------------
                        ------ --------------------------------------------

                        8      Shared Voting Power


                               0
                        ------ -----------------------------------------------

                        9      Sole Dispositive Power


                               0
                        ------ ----------------------------------------------

                        10     Shared Dispositive Power


                               0
----------------------- ------ ----------------------------------------------
--------------- ------------------------------------------------------------
11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                0
--------------- --------------------------------------------------------------
--------------- --------------------------------------------------------------
                                       4




12
                Check if the Aggregate Amount in Row (11) Excludes Certain 
                Shares (See Instructions)
--------------- ------------------------------------------------------------
--------------- --------------------------------------------------------------
13
                Percent of Class Represented by Amount in Row (11)


                0%
--------------- --------------------------------------------------------
14
                Type of Reporting Person (See Instructions)
                OO

--------------- ------------------------------------------------------

                                       5



------------------------------------------------------

 CUSIP No. 766559 10 8
------------------------------------------------------


--------------- --------------------------------------------------------
1               Name of Reporting Persons.   I.R.S.Identification Nos. of above
                persons (entities only).

                FRAZIER HEALTHCARE IV, L.P.
--------------- ---------------------------------------------------------
--------------- ---------------------------------------------------------
2               Check the Appropriate Box if a Member of a Group 
                (See Instructions)

                (a)

                (b)
--------------- ------------------------------------------------------------
--------------- ---------------------------------------------------------

3               SEC Use Only
--------------- ----------------------------------------------------------
--------------- -------------------------------------------------------

4               Source of Funds (See Instructions)


                OO
--------------- -------------------------------------------------------
--------------- -------------------------------------------------------

5               Check if Disclosure of Legal Proceedings Is Required Pursuant 
                to Items 2(d) or 2(e)
--------------- -----------------------------------------------------
--------------- ---------------------------------------------------

6               Citizenship or Place of Organization


                Delaware
--------------- ----------------------------------------------------
----------------------- ------ ---------------------------------------

  Number of             7      Sole Voting Power
  Shares
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With
                        ------ --------------------------------------------
                        ------ ------------------------------------------

                        8      Shared Voting Power


                               0
                        ------ -----------------------------------------

                        9      Sole Dispositive Power


                               0
                        ------ -----------------------------------------

                        10     Shared Dispositive Power


                               0
----------------------- ------ -----------------------------------------
--------------- --------------------------------------------------------
11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                0


--------------- ----------------------------------------------------------

                                       6



--------------- ----------------------------------------------------------
12
                Check if the Aggregate Amount in Row (11) Excludes Certain 
                Shares (See Instructions)
--------------- -----------------------------------------------------------
--------------- -----------------------------------------------------------
13
                Percent of Class Represented by Amount in Row (11)


                0%
--------------- -----------------------------------------------------------
14
                Type of Reporting Person (See Instructions)
                OO

--------------- -----------------------------------------------------------

                                       7



------------------------------------------------------

 CUSIP No. 766559 10 8
------------------------------------------------------


--------------- -----------------------------------------------------------
1               Name of Reporting Persons.   I.R.S.Identification Nos. of above
                persons (entities only).

                FRAZIER AFFILIATES IV, L.P..
--------------- ---------------------------------------------------------
--------------- ----------------------------------------------------------
2               Check the Appropriate Box if a Member of a Group 
                (See Instructions)

                (a)

                (b)
--------------- ----------------------------------------------------------
--------------- --------------------------------------------------------

3               SEC Use Only
--------------- ---------------------------------------------------------
--------------- --------------------------------------------------------

4               Source of Funds (See Instructions)


                OO
--------------- -----------------------------------------------------------
--------------- ----------------------------------------------------------

5               Check if Disclosure of Legal Proceedings Is Required Pursuant 
                to Items 2(d) or 2(e)
--------------- ---------------------------------------------------------
--------------- ---------------------------------------------------------

6               Citizenship or Place of Organization


                Delaware
--------------- --------------------------------------------------------------
----------------------- ------ -----------------------------------------------

  Number of             7      Sole Voting Power
  Shares
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With
                        ------ -----------------------------------------------
                        ------ -----------------------------------------------

                        8      Shared Voting Power


                               0
                        ------ -----------------------------------------------

                        9      Sole Dispositive Power


                               0
                        ------ -----------------------------------------------

                        10     Shared Dispositive Power


                               0
----------------------- ------ -----------------------------------------------
--------------- --------------------------------------------------------------
11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                0
--------------- -----------------------------------------------------------

                                       8



--------------- -----------------------------------------------------------
12
                Check if the Aggregate Amount in Row (11) Excludes Certain 
                Shares (See Instructions)
--------------- ------------------------------------------------------------
--------------- -----------------------------------------------------------
13
                Percent of Class Represented by Amount in Row (11)


                0%
--------------- ------------------------------------------------------------
14
                Type of Reporting Person (See Instructions)
                OO

--------------- --------------------------------------------------------------
                                       9


------------------------------------------------------

 CUSIP No. 766559 10 8
------------------------------------------------------


--------------- -----------------------------------------------------------
1               Name of Reporting Persons.   I.R.S.Identification Nos. of above
                persons (entities only).

                FHM IV, L.P.
--------------- -----------------------------------------------------------
--------------- ----------------------------------------------------------
2               Check the Appropriate Box if a Member of a Group 
                (See Instructions)

                (a)

                (b)
--------------- -------------------------------------------------------------
--------------- -------------------------------------------------------------

3               SEC Use Only
--------------- -------------------------------------------------------------
--------------- -------------------------------------------------------------

4               Source of Funds (See Instructions)


                OO
--------------- -------------------------------------------------------------
--------------- -------------------------------------------------------------

5               Check if Disclosure of Legal Proceedings Is Required Pursuant 
                to Items 2(d) or 2(e)
--------------- --------------------------------------------------------------
--------------- -------------------------------------------------------------

6               Citizenship or Place of Organization


                Delaware
--------------- -------------------------------------------------------------
----------------------- ------ ----------------------------------------------

  Number of             7      Sole Voting Power
  Shares
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With
                        ------ ---------------------------------------------
                        ------ --------------------------------------------

                        8      Shared Voting Power


                               0
                        ------ ----------------------------------------------

                        9      Sole Dispositive Power


                               0
                        ------ ----------------------------------------------

                        10     Shared Dispositive Power


                               0
----------------------- ------ ---------------------------------------------
--------------- ------------------------------------------------------------
11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                0
--------------- -----------------------------------------------------------
                                       10


--------------- ---------------------------------------------------------
12
                Check if the Aggregate Amount in Row (11) Excludes Certain 
                Shares (See Instructions)
--------------- -----------------------------------------------------------
--------------- ---------------------------------------------------------
13
                Percent of Class Represented by Amount in Row (11)


                0%
--------------- -------------------------------------------------------------
14
                Type of Reporting Person (See Instructions)
                OO

--------------- --------------------------------------------------------------

                                       11


------------------------------------------------------

 CUSIP No. 766559 10 8
------------------------------------------------------


--------------- ------------------------------------------------------------
1               Name of Reporting Persons.   I.R.S.Identification Nos. of above
                persons (entities only).

                FHM IV, L.L.C.
--------------- ------------------------------------------------------------
--------------- -------------------------------------------------------------
2               Check the Appropriate Box if a Member of a Group 
                (See Instructions)

                (a)

                (b)
--------------- --------------------------------------------------------------
--------------- --------------------------------------------------------------

3               SEC Use Only
--------------- --------------------------------------------------------------
--------------- -------------------------------------------------------------

4               Source of Funds (See Instructions)


                OO
--------------- --------------------------------------------------------------
--------------- -------------------------------------------------------------

5               Check if Disclosure of Legal Proceedings Is Required Pursuant 
                to Items 2(d) or 2(e)
--------------- -------------------------------------------------------------
--------------- ------------------------------------------------------------

6               Citizenship or Place of Organization


                Delaware
--------------- --------------------------------------------------------------
----------------------- ------ ----------------------------------------------

  Number of             7      Sole Voting Power
  Shares
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With
                        ------ ----------------------------------------------
                        ------ -----------------------------------------------

                        8      Shared Voting Power


                               0
                        ------ --------------------------------------------

                        9      Sole Dispositive Power


                               0
                        ------ ----------------------------------------------

                        10     Shared Dispositive Power


                               0
----------------------- ------ --------------------------------------------
--------------- -------------------------------------------------------------
11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                0
--------------- ------------------------------------------------------------
                                       12


--------------- ------------------------------------------------------------
12
                Check if the Aggregate Amount in Row (11) Excludes Certain 
                Shares (See Instructions)
--------------- -------------------------------------------------------------
--------------- -------------------------------------------------------------
13
                Percent of Class Represented by Amount in Row (11)


                0%
--------------- -----------------------------------------------------------
14
                Type of Reporting Person (See Instructions)
                OO

--------------- ------------------------------------------------------------

                                       13


------------------------------------------------------

 CUSIP No. 766559 10 8
------------------------------------------------------


--------------- -------------------------------------------------------------
1               Name of Reporting Persons.   I.R.S.Identification Nos. of above
                persons (entities only).

                FRAZIER MANAGEMENT, L.L.C.
--------------- ------------------------------------------------------------
--------------- ------------------------------------------------------------
2               Check the Appropriate Box if a Member of a Group 
                (See Instructions)

                (a)

                (b)
--------------- -----------------------------------------------------------
--------------- ---------------------------------------------------------

3               SEC Use Only
--------------- -----------------------------------------------------------
--------------- -------------------------------------------------------------

4               Source of Funds (See Instructions)


                OO
--------------- -----------------------------------------------------------
--------------- -----------------------------------------------------------

5               Check if Disclosure of Legal Proceedings Is Required Pursuant 
                to Items 2(d) or 2(e)
--------------- -----------------------------------------------------------
--------------- -----------------------------------------------------------

6               Citizenship or Place of Organization


                Delaware
--------------- ------------------------------------------------------------
----------------------- ------ ---------------------------------------------

  Number of             7      Sole Voting Power
  Shares
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With
                        ------ ---------------------------------------------
                        ------ --------------------------------------------

                        8      Shared Voting Power


                               0
                        ------ ----------------------------------------------

                        9      Sole Dispositive Power


                               0
                        ------ ---------------------------------------------

                        10     Shared Dispositive Power


                               0
----------------------- ------ ----------------------------------------------
--------------- -------------------------------------------------------------
11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                0
--------------- --------------------------------------------------------------
                                       14


--------------- ------------------------------------------------------------
12
                Check if the Aggregate Amount in Row (11) Excludes Certain 
                Shares (See Instructions)
--------------- -------------------------------------------------------------
--------------- ------------------------------------------------------------
13
                Percent of Class Represented by Amount in Row (11)


                0%
--------------- ----------------------------------------------------------
14
                Type of Reporting Person (See Instructions)
                OO

--------------- -----------------------------------------------------------

                                       15


------------------------------------------------------

 CUSIP No. 766559 10 8
------------------------------------------------------


--------------- --------------------------------------------------------------
1               Name of Reporting Persons.   I.R.S.Identification Nos. of above
                persons (entities only).

                FRAZIER & COMPANY, INC.
--------------- -------------------------------------------------------------
--------------- -------------------------------------------------------------
2               Check the Appropriate Box if a Member of a Group  
                (See Instructions)

                (a)

                (b)
--------------- -------------------------------------------------------------
--------------- ------------------------------------------------------------

3               SEC Use Only
--------------- --------------------------------------------------------------
--------------- -------------------------------------------------------------

4               Source of Funds (See Instructions)


                OO
--------------- -------------------------------------------------------------
--------------- -------------------------------------------------------------

5               Check if Disclosure of Legal Proceedings Is Required Pursuant
                to Items 2(d) or 2(e)
--------------- -------------------------------------------------------------
--------------- -------------------------------------------------------------

6               Citizenship or Place of Organization


                Washington
--------------- -------------------------------------------------------------
----------------------- ------ ----------------------------------------------

  Number of             7      Sole Voting Power
  Shares
  Beneficially
  Owned by                     10,905
  Each
  Reporting
  Person
  With
                        ------ ----------------------------------------------
                        ------ -----------------------------------------------

                        8      Shared Voting Power


                               0
                        ------ ----------------------------------------------

                        9      Sole Dispositive Power


                               10,905
                        ------ ---------------------------------------------

                        10     Shared Dispositive Power


                               0
----------------------- ------ ----------------------------------------------
--------------- ------------------------------------------------------------
11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                10,905
--------------- -------------------------------------------------------------
                                       16



--------------- -------------------------------------------------------------
12
                Check if the Aggregate Amount in Row (11) Excludes Certain 
                Shares (See Instructions)
--------------- -------------------------------------------------------------
--------------- -------------------------------------------------------------
13
                Percent of Class Represented by Amount in Row (11)


                Less than 1%.
--------------- -------------------------------------------------------------
14
                Type of Reporting Person (See Instructions)
                CO

--------------- -------------------------------------------------------------

                                       17


------------------------------------------------------

 CUSIP No. 766559 10 8
------------------------------------------------------


--------------- -------------------------------------------------------------
1               Name of Reporting Persons.   I.R.S.Identification Nos. of above
                persons (entities only).

                ALAN D. FRAZIER
--------------- ------------------------------------------------------------
--------------- ------------------------------------------------------------
2               Check the Appropriate Box if a Member of a Group (See 
                Instructions)

                (a)

                (b)
--------------- --------------------------------------------------------------
--------------- --------------------------------------------------------------

3               SEC Use Only
--------------- --------------------------------------------------------------
--------------- -------------------------------------------------------------

4               Source of Funds (See Instructions)


                OO
--------------- -------------------------------------------------------------
--------------- -------------------------------------------------------------

5               Check if Disclosure of Legal Proceedings Is Required Pursuant  
                to Items 2(d) or 2(e)
--------------- -------------------------------------------------------------
--------------- -------------------------------------------------------------

6               Citizenship or Place of Organization


                United States
--------------- ------------------------------------------------------------
----------------------- ------ ----------------------------------------------

  Number of             7      Sole Voting Power
  Shares
  Beneficially
  Owned by                     19,863 (1)
  Each
  Reporting
  Person
  With
                        ------ --------------------------------------------
                        ------ --------------------------------------------

                        8      Shared Voting Power


                               0
                        ------ --------------------------------------------

                        9      Sole Dispositive Power


                               19,863 (1)
                        ------ ----------------------------------------------

                        10     Shared Dispositive Power


                               0
----------------------- ------ ----------------------------------------------
                                       18


--------------- -------------------------------------------------------------
11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                19,863 (1)
--------------- ------------------------------------------------------------
--------------- -----------------------------------------------------------
12
                Check if the Aggregate Amount in Row (11) Excludes Certain 
                Shares (See Instructions)
--------------- --------------------------------------------------------------
--------------- --------------------------------------------------------------
13
                Percent of Class Represented by Amount in Row (11)


                Less than 1%.
--------------- -------------------------------------------------------------
14
                Type of Reporting Person (See Instructions)
                IN

--------------- -------------------------------------------------------------

(1) Includes  8,958 shares of common stock  issuable  pursuant to stock  options
exercisable within 60 days of January 24, 2005.

                                       19



ITEM 1.  SECURITY AND ISSUER.

         This  statement  relates to shares of Common  Stock of the Issuer.  The
Issuer's  principal  executive offices are located at 1180 Veterans Blvd., South
San Francisco, California, 94080.

ITEM 2.  IDENTITY AND BACKGROUND.

         (a), (f) This  statement  is being filed by Frazier  Healthcare  II, 
L.P., a Delaware  limited  partnership  ("FH II"), FHM II, L.L.C., a Delaware 
limited liability company ("FH II GP"),  Frazier  Healthcare IV, L.P., a 
Delaware limited partnership ("FH IV"),  Frazier  Affiliates IV, L.P., a 
Delaware  limited  partnership ("FA IV"), FHM IV, L.P., a Delaware limited  
partnership  ("FHM IV GPLP"),  FHM IV, L.L.C., a Delaware  limited  liability  
company ("FHM IV GPLLC"),  Frazier Management,  L.L.C.,  a Delaware  limited  
liability  company ("FM"),  Frazier & Company,  Inc., a Washington  corporation
("F&Co.") and Alan D. Frazier ("AF"),  a natural person and a citizen of the 
United States  (collectively,  the "Reporting Persons").

         FH II GP is the general  partner of FH II. F&Co. is the managing member
of FM, which in turn is the managing member of FH II GP.

         FHM IV GPLLC is the  general  partner of FHM IV GPLP,  which in turn is
the general  partner of both FH IV and FA IV. AF is a member of FHM IV GPLLC. AF
is the controlling  shareholder of F&Co. and serves as a director of the Issuer.
FM serves as the management  company of FH IV and FA IV. F&Co. also is a limited
partner of FH IV and FH II.

         (b) The address of the principal  business and principal  office of the
Reporting  Persons is Two Union Square,  601 Union  Street,  Suite 3200 Seattle,
Washington, 98101.

         (c) FH II, FA IV and FH IV are venture capital funds  concentrating  in
healthcare and related fields.  The principal  business of FH II GP, FHM IV GPLP
and FHM IV GPLLC is to serve as general  partner  entities  to  venture  capital
funds. The principal business of FM is to provide management services to venture
capital  funds.  F&Co.  is a family  holding  company  for AF.  AF is a  venture
capitalist.

         (d)  During  the  five  years  prior to the  date  hereof,  none of the
Reporting Persons has been convicted in a criminal proceeding (excluding traffic
violations or similar misdemeanors).

         (e)  During  the  five  years  prior to the  date  hereof,  none of the
Reporting  Persons has been a party to a civil proceeding  ending in a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, federal or state securities laws or finding any
violation with respect to such laws.

ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

         On May 20,  2004 FH IV  completed  a prorata  distribution  of  459,564
shares of common stock of Issuer to its partners. In connection with the prorata
distribution,  an  aggregate  of 2,012  shares  of common 

                                       20


stock of Issuer  were distributed  to F&Co.  Also on May 20,  2004,  FA IV sold
2,333 shares of common stock of Issuer at a price of $17.61 per share.

         On January 24, 2005 FH IV completed a prorata  distribution  of 459,563
shares of common  stock of Issuer to its  partners and FH II completed a prorata
distribution  of 481,396  shares of common stock of Issuer to its  partners.  In
connection with these prorata  distributions,  FH IV distributed 2,118 shares of
common  stock of Issuer to F&Co.  and FH II  distributed  2,799 shares of common
stock of Issuer to F&Co.  On January 25, 2005 FA IV sold 2,332  shares of common
stock of Issuer at a price of $19.10 per share.

ITEM 4.  PURPOSE OF TRANSACTION

         The  Reporting  Persons have  acquired and disposed of shares of common
stock of Issuer for investment purposes. AF is a director of the Issuer.

         Depending on market conditions,  continuing  evaluation of the business
and prospects of the Issuer and other factors, the Reporting Persons may dispose
of or  acquire  additional  shares  of the  common  stock of  Issuer  or  pursue
strategic transactions as opportunities arise.

         Except as set forth above, the Reporting  Persons have no present plans
or  intentions  which  would  result  in or  relate  to any of the  transactions
described in Item 4 of this Amendment No. 2 to Schedule 13D.

ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER.

         (a) As a result of the most recent sale and  distribution  of shares of
Issuer as  described  in Item 3 above and prior  acquisitions  of Issuer  stock,
F&Co.  is the record holder of 10,905 shares of common stock of Issuer and AF is
the record  holder of 10,000  options to  purchase  common  stock of the Issuer,
8,958 of which are  exercisable  within 60 days of January  24,  2005.  No other
Reporting  Persons are record  holders of securities of the Issuer.  Each of the
Reporting  Persons  expressly  disclaim  beneficial  ownership  of any shares of
common stock or options to purchase common stock, except for such securities for
which such Reporting Person is the holder of record.

         (b) AF is the  president  and  controlling  shareholder  of F&Co.,  the
record  holder of 10,905  shares of common stock of Issuer.  AF is the holder of
options to purchase 8,958 shares of common stock of Issuer exercisable within 60
days of January 25, 2005.

         (c) On May 20, 2004 FH IV completed a prorata  distribution  of 459,564
shares of common stock of Issuer to its partners. In connection with the prorata
distribution,  an  aggregate  of 2,012  shares  of common  stock of Issuer  were
distributed  to F&Co.  Also on May 20,  2004,  FA IV sold 2,333 shares of common
stock of Issuer at a price of $17.61  per  share.  On January  24,  2005,  FH IV
completed a prorata  distribution of 459,563 shares of common stock of Issuer to
its partners, FH II completed a prorata distribution of 481,396 shares of common
stock of Issuer to its partners. On January 25, 2005, FA IV sold 2,332 shares of
common  stock of Issuer at a price of $19.10  per share.  No other  transactions
were effected by the Reporting Persons in the last sixty days.

         (d) No other  person is known to have the right to receive or the power
to direct the receipt of dividends  from,  or any proceeds from the sale of, any
securities beneficially owned by the Reporting Persons.

                                       21


         (e) Not applicable.

ITEM 6.  CONTRACTS, ARRANGEMENTS, UNDERTAKINGS OR RELATIONSHIPS WITH
                  RESPECT TO SECURITIES OF THE ISSUER.

         The information provided in Schedule 13D filed by the Reporting Persons
on July 7, 2003 and  Amendment  No. 1 to  Schedule  13D  filed by the  Reporting
Persons  on April 14,  2004,  together  with the  information  provided  in this
Amendment No. 2 to Schedule 13D is hereby incorporated by reference.

ITEM 7.  MATERIAL TO BE FILED AS EXHIBITS.

         Not applicable.

                                    SIGNATURE

         After  reasonable  inquiry and to the best of its knowledge and belief,
each of the  undersigned  certifies  that  the  information  set  forth  in this
statement is true, complete and correct.



Date:  January 26, 2004
                          FRAZIER HEALTHCARE II, L.P.
                            By: FHM II, L.L.C.
                                Its General Partner
                            By: Frazier Management, L.L.C.
                                Its Managing Member


                                       By:  /s/ Thomas S. Hodge          
                                               Thomas S. Hodge
                                               Chief Operating Officer

                          FHM II, L.L.C.
                             By: Frazier Management, L.L.C.
                                 Its Managing Member

                                  By:  /s/ Thomas S. Hodge                  
                                      Thomas S. Hodge, Chief Operating Officer

                           FRAZIER HEALTHCARE IV, L.P.
                           By: FHM IV, L.P.
                               Its General Partner
                               By:  FHM IV, L.L.C.
                                    Its General Partner

                                     By:  /s/ Thomas S. Hodge        
                                              Thomas S. Hodge
                                              Chief Operating Officer

                                       22


                           FRAZIER AFFILIATES IV, L.P.
                           By: FHM IV, L.P.
                               Its General Partner
                               By: FHM IV, L.L.C.
                                   Its General Partner

                                    By:  /s/ Thomas S. Hodge          
                                             Thomas S. Hodge
                                             Chief Operating Officer

                           FHM IV, L.P.
                           By:    FHM IV, L.L.C.
                                  Its General Partner

                                       By:  /s/ Thomas S. Hodge           
                                            Thomas S. Hodge
                                            Chief Operating Officer

                            FHM IV, L.L.C.

                                 By:  /s/ Thomas S. Hodge                
                                      Thomas S. Hodge, Chief Operating Officer

                                 FRAZIER MANAGEMENT, L.L.C.


                                 By:  /s/ Thomas S. Hodge                
                                      Thomas S. Hodge, Chief Operating Officer

                                 FRAZIER & COMPANY, INC.

                                 By:  /s/ Alan D. Frazier              
                                         Alan D. Frazier, President
                                         Director and Shareholder

                            ALAN D. FRAZIER

                            /s/ Alan D. Frazier   



                                       23