FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0104 Expires: January 31, 2005 Estimated average burden hours per response... 0.5

(Print or Type Responses)

1. Name and Address of Reporting Person *   Weber Kathleen Gallagher 2. Date of Event Requiring Statement (Month/Day/Year) 01/01/2019 3. Issuer Name and Ticker or Trading Symbol ORASURE TECHNOLOGIES INC [OSUR] (Last) (First) (Middle) 220 EAST FIRST STREET 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) EVP & BU Lead - Molecular 5. If Amendment, Date Original Filed(Month/Day/Year) (Street) BETHLEHEM, PA 18015-1360 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5) Common Stock (1) 9,066 (2) D   Common Stock (1) 9,100 (3) D   Common Stock (1) 8,008 (4) D Â

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Option (right to buy)	02/03/2015(5)	02/03/2024	Common Stock	4,129	$ 5.7149	D	Â
Option (right to buy)	02/03/2016(6)	02/03/2025	Common Stock	10,404	$ 9.31	D	Â

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Weber Kathleen Gallagher 220 EAST FIRST STREET BETHLEHEM, PA 18015-1360	Â	Â	  EVP & BU Lead - Molecular	Â

Signatures

/s/Jack E. Jerrett As Attorney-In-Fact For Kathleen G. Weber		01/04/2019
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	RSA with vesting schedule
(2)	Grant of restricted shares under OraSure Technologies, Inc. Stock Award Plan, all of which vest February 1, 2019. Vesting shall cease upon voluntary termination of employment.
(3)	Grant of restricted shares under OraSure Technologies, Inc. Stock Award Plan, one-half of which vest on February 1, 2019 and the other half on February 1, 2020. Vesting shall cease upon voluntary termination of employment.
(4)	Grant of restricted shares under OraSure Technologies, Inc. Stock Award Plan, one third of which vest on February 1, 2019, the second third on February 1, 2020 and the final third on February 1, 2021. Vesting shall cease upon voluntary termination of employment.
(5)	Non-qualified stock options granted on February 3, 2014, vesting 25% at the end of 12 months after the grant date and 75% ratably on a monthly basis over the next 36 months. Vesting shall cease upon voluntary termination of employment.
(6)	Non-qualified stock options granted on February 3, 2015, vesting 25% at the end of 12 months after the grant date and 75% ratably on a monthly basis over the next 36 months. Vesting shall cease upon voluntary termination of employment.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.