*
|
The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
|
CUSIP No. 268158102
|
13G/A
|
Page 2 of 16 Pages
|
1.
|
NAMES OF REPORTING PERSONS
Vivo Ventures VI, LLC
|
||
2.
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) ¨
(b) ý
|
||
3.
|
SEC USE ONLY
|
||
4.
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF SHARES
BENEFICIALLY OWNED
BY EACH REPORTING
PERSON WITH
|
5.
|
SOLE VOTING POWER
- 0 -
|
|
6.
|
SHARED VOTING POWER
3,356,373
|
||
7.
|
SOLE DISPOSITIVE POWER
- 0 -
|
||
8.
|
SHARED DISPOSITIVE POWER
3,356,373
|
||
9.
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
3,356,373
|
||
10.
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ¨
|
||
11.
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
2.6%(1)
|
||
12.
|
TYPE OF REPORTING PERSON
OO
|
CUSIP No. 268158102
|
13G/A
|
Page 3 of 16 Pages
|
1.
|
NAMES OF REPORTING PERSONS
Vivo Ventures Fund VI, L.P.
|
||
2.
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) ¨
(b) ý
|
||
3.
|
SEC USE ONLY
|
||
4.
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF SHARES
BENEFICIALLY OWNED
BY EACH REPORTING
PERSON WITH
|
5.
|
SOLE VOTING POWER
- 0 -
|
|
6.
|
SHARED VOTING POWER
3,331,982
|
||
7.
|
SOLE DISPOSITIVE POWER
- 0 -
|
||
8.
|
SHARED DISPOSITIVE POWER
3,331,982
|
||
9.
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
3,331,982
|
||
10.
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ¨
|
||
11.
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
2.6%(1)
|
||
12.
|
TYPE OF REPORTING PERSON
PN
|
CUSIP No. 268158102
|
13G/A
|
Page 4 of 16 Pages
|
1.
|
NAMES OF REPORTING PERSONS
Vivo Ventures VI Affiliates Fund, L.P.
|
||
2.
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) ¨
(b) ý
|
||
3.
|
SEC USE ONLY
|
||
4.
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
|
5.
|
SOLE VOTING POWER
- 0 -
|
|
6.
|
SHARED VOTING POWER
24,391
|
||
7.
|
SOLE DISPOSITIVE POWER
- 0 -
|
||
8.
|
SHARED DISPOSITIVE POWER
24,391
|
||
9.
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
24,391
|
||
10.
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ¨
|
||
11.
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
<0.1%(1)
|
||
12.
|
TYPE OF REPORTING PERSON
PN
|
CUSIP No. 268158102
|
13G/A
|
Page 5 of 16 Pages
|
1.
|
NAMES OF REPORTING PERSONS
Vivo Ventures V, LLC
|
||
2.
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) ¨
(b) ý
|
||
3.
|
SEC USE ONLY
|
||
4.
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
|
5.
|
SOLE VOTING POWER
- 0 -
|
|
6.
|
SHARED VOTING POWER
790,693
|
||
7.
|
SOLE DISPOSITIVE POWER
- 0 -
|
||
8.
|
SHARED DISPOSITIVE POWER
790,693
|
||
9.
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
790,693
|
||
10.
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ¨
|
||
11.
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
0.6%(1)
|
||
12.
|
TYPE OF REPORTING PERSON
OO
|
CUSIP No. 268158102
|
13G/A
|
Page 6 of 16 Pages
|
1.
|
NAMES OF REPORTING PERSONS
Vivo Ventures Fund V, L.P.
|
||
2.
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) ¨
(b) ý
|
||
3.
|
SEC USE ONLY
|
||
4.
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
|
5.
|
SOLE VOTING POWER
- 0 -
|
|
6.
|
SHARED VOTING POWER
781,490
|
||
7.
|
SOLE DISPOSITIVE POWER
- 0 -
|
||
8.
|
SHARED DISPOSITIVE POWER
781,490
|
||
9.
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
781,490
|
||
10.
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ¨
|
||
11.
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
0.6%(1)
|
||
12.
|
TYPE OF REPORTING PERSON
PN
|
CUSIP No. 268158102
|
13G/A
|
Page 7 of 16 Pages
|
1.
|
NAMES OF REPORTING PERSONS
Vivo Ventures V Affiliates Fund, L.P.
|
||
2.
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) ¨
(b) ý
|
||
3.
|
SEC USE ONLY
|
||
4.
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
|
5.
|
SOLE VOTING POWER
- 0 -
|
|
6.
|
SHARED VOTING POWER
9,203
|
||
7.
|
SOLE DISPOSITIVE POWER
- 0 -
|
||
8.
|
SHARED DISPOSITIVE POWER
9,203
|
||
9.
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
9,203
|
||
10.
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ¨
|
||
11.
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
<0.1%(1)
|
||
12.
|
TYPE OF REPORTING PERSON
PN
|
CUSIP No. 268158102
|
13G/A
|
Page 8 of 16 Pages
|
Item 1(a).
|
Name of Issuer:
|
Item 1(b).
|
Address of Issuer’s Principal Executive Offices:
|
Item 2(a).
|
Name of Persons Filing:
|
Item 2(b).
|
Address of Principal Business Office or, if None, Residence:
|
Item 2(c).
|
Citizenship:
|
CUSIP No. 268158102
|
13G/A
|
Page 9 of 16 Pages
|
Item 2(d).
|
Title of Class of Securities:
|
Item 2(e).
|
CUSIP Number:
|
(a)
|
o
|
Broker or dealer registered under Section 15 of the Act;
|
|
(b)
|
o
|
Bank as defined in Section 3(a)(6) of the Act;
|
|
(c)
|
o
|
Insurance company as defined in Section 3(a)(19) of the Act;
|
|
(d)
|
o
|
Investment company registered under Section 8 of the Investment Company Act of 1940;
|
|
(e)
|
o
|
An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);
|
|
(f)
|
o
|
An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);
|
|
(g)
|
o
|
A parent holding company or control person in accordance with §240.13d-1 (b)(1)(ii)(G);
|
|
(h)
|
o
|
A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act;
|
|
(i)
|
o
|
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act;
|
|
(j)
|
o
|
A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J);
|
|
(k)
|
o
|
Group, in accordance with §240.13d-1(b)(1)(ii)(K).
|
Item 4.
|
Ownership.
|
CUSIP No. 268158102
|
13G/A
|
Page 10 of 16 Pages
|
Reporting Person
|
Percent
|
Vivo Ventures VI, LLC
|
2.6%
|
Vivo Ventures Fund VI, L.P.
|
2.6%
|
Vivo Ventures VI Affiliates Fund, L.P.
|
<0.1%
|
Vivo Ventures V, LLC
|
0.6%
|
Vivo Ventures Fund V, L.P.
|
0.6%
|
Vivo Ventures V Affiliates Fund, L.P.
|
<0.1%
|
Reporting Person
|
Shares
|
Vivo Ventures VI, LLC
|
3,356,373
|
Vivo Ventures Fund VI, L.P.
|
3,331,982
|
Vivo Ventures VI Affiliates Fund, L.P.
|
24,391
|
Vivo Ventures V, LLC
|
790,693
|
Vivo Ventures Fund V, L.P.
|
781,490
|
Vivo Ventures V Affiliates Fund, L.P.
|
9,203
|
Reporting Person
|
Shares
|
Vivo Ventures VI, LLC
|
3,356,373
|
Vivo Ventures Fund VI, L.P.
|
3,331,982
|
Vivo Ventures VI Affiliates Fund, L.P.
|
24,391
|
Vivo Ventures V, LLC
|
790,693
|
Vivo Ventures Fund V, L.P.
|
781,490
|
Vivo Ventures V Affiliates Fund, L.P.
|
9,203
|
Item 5.
|
Ownership of Five Percent or Less of a Class.
|
CUSIP No. 268158102
|
13G/A
|
Page 11 of 16 Pages
|
Item 6.
|
Ownership of More than Five Percent on Behalf of Another Person.
|
Item 7.
|
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
|
Item 8.
|
Identification and Classification of Members of the Group.
|
Item 9.
|
Notice of Dissolution of Group.
|
Item 10.
|
Certification.
|
CUSIP No. 268158102
|
13G/A
|
Page 12 of 16 Pages
|
VIVO VENTURES VI, LLC
By: /s/ Frank Kung
Name: Frank Kung
Title: Managing Member
VIVO VENTURES FUND VI, L.P.
By: Vivo Ventures VI, LLC, its general partner
By: /s/ Frank Kung
Name: Frank KungTitle: Managing Member
VIVO VENTURES VI AFFILIATES FUND, L.P.
By: Vivo Ventures VI, LLC, its general partner
By: /s/ Frank Kung
Name: Frank KungTitle: Managing Member
VIVO VENTURES V, LLC
By: /s/ Frank Kung
Name: Frank Kung Title: Managing Member
VIVO VENTURES FUND V, L.P.
By: Vivo Ventures V, LLC, its general partner
By: /s/ Frank Kung
Name: Frank Kung Title: Managing Member
|
CUSIP No. 268158102
|
13G/A
|
Page 13 of 16 Pages
|
VIVO VENTURES V AFFILIATES FUND, L.P.
By: Vivo Ventures V, LLC, its general partner
By:
By: /s/ Frank Kung
Name: Frank Kung
Title: Managing Member
|
CUSIP No. 268158102
|
13G/A
|
Page 14 of 16 Pages
|
Exhibit Number
|
Exhibit Description
|
1
|
Joint Filing Agreement
|
CUSIP No. 268158102
|
13G/A
|
Page 15 of 16 Pages
|
VIVO VENTURES VI, LLC
By: /s/ Frank Kung
Name: Frank Kung
Title: Managing Member
VIVO VENTURES FUND VI, L.P.
By: Vivo Ventures VI, LLC, its general partner
By: /s/ Frank Kung
Name: Frank KungTitle: Managing Member
VIVO VENTURES VI AFFILIATES FUND, L.P.
By: Vivo Ventures VI, LLC, its general partner
By: /s/ Frank Kung
Name: Frank KungTitle: Managing Member
|
CUSIP No. 268158102
|
13G/A
|
Page 16 of 16 Pages
|
VIVO VENTURES V, LLC
By: /s/ Frank Kung
Name: Frank Kung
Title: Managing Member
VIVO VENTURES FUND V, L.P.
By: Vivo Ventures V, LLC, its general partner
By: /s/ Frank Kung
Name: Frank Kung
Title: Managing Member
VIVO VENTURES V AFFILIATES FUND, L.P.
By: Vivo Ventures V, LLC, its general partner
By: /s/ Frank Kung
Name: Frank Kung Title: Managing Member
|