Alvin Kamara rushed for a touchdown to become the Saints’ career TD leader, Derek Carr had two scoring passes and New Orleans routed the New England Patriots 34-0 on Sunday.

Tyrann Mathieu added a 27-yard interception return for a touchdown to help New Orleans (3-2) chase Patriots quarterback Mac Jones from the game — the second straight week coach Bill Belichick sidelined Jones in the second half.

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Kamara punched in his 73rd career TD, one of his 22 carries for 80 yards. Carr finished 18 of 26 for 183 yards, and Michael Thomas had four catches for 65 yards as New Orleans ended a two-game skid.

It was the second-worst shutout loss in team history for New England, trailing only a 52-0 drubbing in Miami against the undefeated Dolphins in 1972. It also drops the Patriots to 1-4 for the first time since 2000, Belichick’s first season in New England.

He remains a win short of joining Hall of Famers Don Shula and George Halas as the only coaches in NFL history with 300 regular-season victories.

Jones was 12 of 22 for 110 yards, the pick-6 and another interception that set up a Saints touchdown. He also lost a fumble in the third quarter that was recovered by Cameron Jordan and set up a Saints’ field goal. He was replaced by backup Bailey Zappe in the fourth quarter.