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Seattle Genetics Announces Presentations of New Clinical Data from Multiple Studies of Novel Targeted Therapies at the American Society of Clinical Oncology (ASCO) Annual Meeting

Seattle Genetics, Inc. (Nasdaq:SGEN) today announced data from six of its proprietary programs will be presented at the upcoming American Society of Clinical Oncology (ASCO) 2019 Annual Meeting taking place May 31 to June 4, 2019 in Chicago. More than 10 sessions at the meeting will feature Seattle Genetics’ approved or investigational therapies, including an oral presentation of the results from the enfortumab vedotin pivotal trial. The abstracts published in advance of the ASCO meeting were made available today on the ASCO website at www.asco.org.

“Data to be presented on our approved or investigational targeted medicines support our efforts toward becoming a multi-product oncology company,” said Roger Dansey, M.D., Chief Medical Officer at Seattle Genetics. “Importantly, the oral presentation of the results from the EV-201 pivotal trial of enfortumab vedotin in patients with locally advanced or metastatic urothelial cancer is our first solid tumor late-stage development program. We are also presenting updated analyses from the ECHELON-1 and ECHELON-2 frontline phase 3 trials of ADCETRIS® (brentuximab vedotin) that is approved for several types of lymphomas.”

Details of the oral presentation:

Abstract Title: EV-201: Results of Enfortumab Vedotin Monotherapy for Locally Advanced or Metastatic Urothelial Cancer Previously Treated with Platinum and Immune Checkpoint Inhibitors

Abstract: #LBA4505

Presenter: Daniel P. Petrylak, M.D., Yale School of Medicine

Date and Time: Monday, June 3, 9:24-9:36 a.m. CDT

Location: Arie Crown Theater

Details of select company- or investigator-sponsored presentations are as follows:

Brentuximab Vedotin with Chemotherapy for Stage 3/4 Classical Hodgkin Lymphoma: Three-year Update of the ECHELON-1 Study (Abstract #7532)

Date and Time: Monday, June 3, 8:00 a.m.-11:00 a.m. CDT

Location: Hall A, Poster Board #286

Response to A+CHP by CD30 Expression in the ECHELON-2 Trial (Abstract #7538)

Date and Time: Monday, June 3, 8:00 a.m.-11:00 a.m. CDT

Location: Hall A, Poster Board #292

Response to Brentuximab Vedotin by CD30 Expression: Results from Five Trials in PTCL, CTCL, and B-cell Lymphomas (Abstract #7543)

Date and Time: Monday, June 3, 8:00 a.m.-11:00 a.m. CDT

Location: Hall A, Poster Board #297

Tucatinib, Palbociclib, and Letrozole in HR+/HER2+ Metastatic Breast Cancer: Report of Phase IB Safety Cohort (Abstract #1029)

Date and Time: Sunday, June 2, 8:00 a.m.-11:00 a.m. CDT

Location: Hall A, Poster Board #110

Performance of FACT-GOG-Ntx to Assess Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Pediatric Hodgkin lymphoma (HL) Patients (Abstract #10064)

Date and Time: Saturday, June 1, 8:00 a.m.-11:00 a.m. CDT

Location: Hall A, Poster Board #446

Details of company-sponsored trials in progress presentations are as follows:

SGNTV-001: Open Label Phase 2 Study of Tisotumab Vedotin for Locally Advanced or Metastatic Disease in Solid Tumors (Abstract #TPS3160)

Date and Time: Saturday, June 1, 8:00 a.m.-11:00 a.m. CDT

Location: Hall A, Poster Board #145a

Phase 2 Trial of Tisotumab Vedotin in Platinum-Resistant Ovarian Cancer (innovaTV 208) (Abstract #TPS5602)

Date and Time: Saturday, June 1, 1:15 p.m.-4:15 p.m. CDT

Location: Hall A, Poster Board #421a

SGNLVA-002: Single-Arm, Open Label Phase IB/II Study of Ladiratuzumab Vedotin (LV) in Combination with Pembrolizumab for First-Line Treatment of Patients with Unresectable Locally Advanced or Metastatic Triple-Negative Breast Cancer (Abstract #TPS1110)

Date and Time: Sunday, June 2, 8:00 a.m.-11:00 a.m. CDT

Location: Hall A, Poster Board #186a

SGNBCMA-001: A Phase 1 Study of SEA-BCMA, a Non-Fucosylated Monoclonal Antibody, in Subjects with Relapsed or Refractory Multiple Myeloma (Abstract #TPS8054)

Date and Time: Monday, June 3, 8:00 a.m.-11:00 a.m. CDT

Location: Hall A, Poster Board #379a

EV-103: Enfortumab Vedotin Plus Pembrolizumab and/or Chemotherapy for Locally Advanced or Metastatic Urothelial Cancer (Abstract #TPS4593)

Date and Time: Monday, June 3, 1:15 p.m.-4:15 p.m. CDT

Location: Hall A, Poster Board #415b

About Seattle Genetics

Seattle Genetics, Inc. is an emerging multi-product, global biotechnology company that develops and commercializes transformative therapies targeting cancer to make a meaningful difference in people’s lives. ADCETRIS® (brentuximab vedotin) utilizes the company’s industry-leading antibody-drug conjugate (ADC) technology and is currently approved for the treatment of multiple CD30-expressing lymphomas. Beyond ADCETRIS, the company has established a pipeline of novel targeted therapies at various stages of clinical testing, including three in ongoing pivotal trials for solid tumors. Enfortumab vedotin for metastatic urothelial cancer and tisotumab vedotin for metastatic cervical cancer utilize our proprietary ADC technology. Tucatinib, a small molecule tyrosine kinase inhibitor, is in a pivotal trial for HER2-positive metastatic breast cancer. In addition, we are leveraging our expertise in empowered antibodies to build a portfolio of proprietary immuno-oncology agents in clinical trials targeting hematologic malignancies and solid tumors. The company is headquartered in Bothell, Washington, and has a European office in Switzerland. For more information on our robust pipeline, visit www.seattlegenetics.com and follow @SeattleGenetics on Twitter.

Forward-Looking Statements

Certain of the statements made in this press release are forward looking, such as those, among others, relating to the possible utility or application of the Company’s technologies to develop therapeutic agents, therapeutic potential of investigational agents, and future development activities including clinical trials. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the difficulty and uncertainty of pharmaceutical product development, including the risks that Seattle Genetics may experience delays in its planned clinical trial initiations or otherwise experience failures or setbacks in its preclinical and clinical development programs due to the potential lack of efficacy or risk of adverse events or other factors. More information about the risks and uncertainties faced by Seattle Genetics is contained under the caption “Risk Factors” included in the company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2019 filed with the Securities and Exchange Commission. Seattle Genetics disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Contacts:

Media:
Monique Greer
(425) 527-4641
mgreer@seagen.com

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