New York, March 13, 2019 Creative Biolabs, a leading custom service provider, launches a full range of structure-based antibody reformatting services to obtain an ideal antibody fragment with good stability, high affinity, and preeminent specificity.
As is known, antibodies are comprised of two heavy and two light chains that both contribute to the antigen-binding site. Besides altering the Fc portion of an antibody, the variable region of an immunoglobulin enables to be reformatted into a number of different fragments, including Fab, F(ab)’2, scFv, VHH antibodies, and minibodies, which are characterized by smaller antibody formats, increased tumour/tissue penetration, as well as relative ease of expression in non-mammalian systems, therefore playing an increasingly important role in drug discovery and clinical research.
In Creative Biolabs, the target antibody molecule can maintain a relatively stable physicochemical property after reformatting and keep the original affinity and function. In addition, the external environment of the modified molecular model can be set up and evaluated by RMSD, RMSF, as well as the potential energy inside the molecule.
“In general, engineering antibodies with enhanced properties, such as stability, have commonly been accomplished by mutating single or combinations of key amino acid residues. In order to accelerate the structure determination process and offer better service for reformatting VHH and scFv antibodies, we have developed an advanced in silico platform comprised several techniques, such as homology modeling, molecular dynamics simulation, in-house algorithm, and antibody molecule model analysis. By means of these advanced techniques, we are able to identify the main residues affecting the certain characteristic of the target antibody, and then the mutation on these amino acid residues can be performed.” said a scientist in Creative Biolabs.
With the comprehensive structure-based antibody reformatting platform, Creative Biolabs can not only provide high quality scFv reformatting services but also customize the service according to the specific requirements from the customers. More details can be found at https://www.creative-biolabs.com/preciab.
About Creative Biolabs
Creative Biolabs was founded by scientists who are dedicated to the conquering of cancer, believing that a custom-service-centered business model is important for optimizing the drug development process, leveraging accessible resources, and forming a team of various background to conduct drug discovery in future. The service portfolio includes mouse and rat monoclonal antibody production using hybridoma technology, human, monkey, rabbit, chicken, dog, llama and camel monoclonal antibody production using various antibody library technologies (including phage display, bacterial display and yeast display). In addition, OEM services for bulk scale antibody manufacturing, including bacterial production of scFv, diabody, tandem scFv, miniantibody and Fab, and mammalian cell expression of minibody, chimeric IgG and IgG, are also available at the most competitive price in the industry.
Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-619-7922
Address:45-1 Ramsey Road
City: Shirley
State: New York
Country: United States
Website: https://www.creative-biolabs.com/preciab
Source: www.abnewswire.com
