Crude oil prices edged up again to lift the markets to a higher close with the Dow slipping 2 points to 21,394. Nasdaq climbed 28 points to 6,265.

On the upside

Cowen initiated coverage of AdvanSix (NYSE: ASIX) with an Outperform rating.

Bargain hunters continued to snap up shares of EQT (NYSE: EQT).

The Food and Drug Administration approved Portola Pharmaceuticals' (Nasdaq: PTLA) blood clot prevention drug Bevyxxa.

On the downside

Investors locked in profits on InVivo Therapeutics (Nasdaq: NVIV).

Quantitative Investment Management slashed its stake in Sysco (NYSE: SYY) by 62.5%.

Profit taking weighed down shares of Infinity Pharmaceuticals (Nasdaq: INFI).

In the broad market, advancing issues outpaced decliners by a margin of more than 2 to 1 on the NYSE and by more than 5 to 3 on Nasdaq. The broader S&P 500 added 3 points to 2,438. Bitcoin fell $9 to $2682.