Research Highlights:

• An analysis of more than 202,000 heart attack deaths between 2015-2020 in a single Chinese province found that days that had extreme heat, extreme cold or high levels of fine particulate matter (PM_2.5) air pollution were significantly associated with the risk of death from a heart attack, especially in women and older adults.
• The greatest increase in the risk of death from heart attack was seen on days that had the combination of extreme heat and high levels of PM_2.5.
• The days with extreme heat were associated with an increased risk of heart attack death in women vs. men, and in older adults than in younger adults. Older adults were also at a greater risk of heart attacks compared to younger adults during days with extreme cold or high levels of PM_2.5.

Embargoed until 1 p.m. CT/2 p.m. ET Monday, July 24, 2023

(NewMediaWire) - July 24, 2023 - DALLAS — The combination of soaring heat and smothering fine particulate pollution may double the risk of heart attack death, according to a new study of more than 202,000 heart attack deaths in China. The study published today in the American Heart Association’s flagship journal Circulation.

“Extreme temperature events are becoming more frequent, longer and more intense, and their adverse health effects have drawn growing concern. Another environmental issue worldwide is the presence of fine particulate matter in the air, which may interact synergistically with extreme temperatures to adversely affect cardiovascular health,” said senior author Yuewei Liu, M.D., Ph.D., an associate professor of epidemiology in the School of Public Health at Sun Yat-sen University in Guangzhou, China. “However, it remains unknown if and how co-exposure to extreme temperatures and fine particulate pollution might interact to trigger a greater risk of death from heart attack, which is an acute response potentially brought on by an acute scenario and a great public health challenge due to its substantial disease burden worldwide.”

To examine the impact of extreme temperatures with and without high levels of fine particulate pollution, the researchers analyzed 202,678 heart attack deaths between 2015-2020 that occurred in Jiangsu province, a region with four distinct seasons and a wide range of temperatures and fine particulate pollution levels. The deaths were among older adults with an average age of 77.6 years; 52% were older than age 80; and 52% were male. Particulate exposure on the day of each death and one day before death were included in the analysis.

Extreme temperatures were gauged according to the daily heat index (also referred to as apparent temperature) for an area, which captures the combined effect of both heat and humidity. Both the length and extremeness of heat waves and cold snaps were evaluated. Heart attack deaths, or case days, during these periods were compared with control days on the same day of the week in the same month — meaning that if a death occurred on a Wednesday, all other Wednesdays in the same month would be considered control days. Particulate levels were considered high on any day with an average level of fine particulate matter above 37.5 micrograms per cubic meter.

“Our findings provide evidence that reducing exposure to both extreme temperatures and fine particulate pollution may be useful to prevent premature deaths from heart attack, especially for women and older adults,” Liu said.

Compared with control days, the risk of a fatal heart attack was observed at the following levels:

• 18% higher during ­2-day heat waves with heat indexes at or above the 90^th percentile (ranging from 82.6 to 97.9 degrees Fahrenheit), increasing with temperature and duration, and was 74% higher during 4-day heat waves with heat indexes at or above the 97.5^th percentile (ranging from 94.8 to 109.4 degrees Fahrenheit). For context, 6,417 (3.2%) of the 202,678 observed deaths from heart attack happened during heat waves with heat indexes at or above the 95^th percentile (ranging from 91.2 to 104.7 degrees Fahrenheit) for three or more days.
• 4% higher during 2-day cold snaps with temperatures at or below the 10^th percentile (ranging from 33.3 to 40.5 degrees Fahrenheit), increasing with lower temperatures and duration, and was 12% higher during 3-day cold snaps with temperatures at or below the 2.5^th percentile (ranging from 27.0 to 37.2 degrees Fahrenheit). For context, 6,331 (3.1%) of the 202,678 observed deaths from heart attack happened during cold spells with temperatures at or below the 5^th percentile (ranging from 30.0 to 38.5 degrees Fahrenheit) for 3 or more days.
• Twice as high during 4-day heat waves that had fine particulate pollution above 37.5 micrograms per cubic meter. Days with high levels of fine particulate pollution during cold snaps did not have an equivalent increase in the risk of heart attack death.
• Generally higher among women than men during heat waves.
• Higher among people ages 80 and older than in younger adults during heat waves, cold snaps or days with high levels of fine particulate pollution.
• The mean age of all individuals who died from a heart attack in Jiangsu from 2015-2020, including during non-extreme temperature events, was 77.6 years old; 52.1% of these individuals were over 80 years old.

The researchers estimated that up to 2.8% of heart attack deaths may be attributed to the combination of extreme temperatures and high levels of fine particulate pollution (> 37.5 micrograms per cubic meter), according to WHO targets.

“Strategies for individuals to avoid negative health effects from extreme temperatures include following weather forecasts, staying inside when temperatures are extreme, using fans and air conditioners during hot weather, dressing appropriately for the weather, proper hydration and installing window blinds to reduce indoor temperatures,” said Liu. “Using an air purifier in the house, wearing a mask outdoors, staying clear of busy highways when walking and choosing less-strenuous outdoor activities may also help to reduce exposure to air pollution on days with high levels of fine particulate pollution. To improve public health, it is important to take fine particulate pollution into consideration when providing extreme temperature warnings to the public.”

In a 2020 scientific statement and a 2020 policy statement, the American Heart Association details the latest science about air pollution exposure and the individual, industrial and policy measures to reduce the negative impact of poor air quality on cardiovascular health. Reducing exposure to air pollution and reversing the negative impact of poor air quality on cardiovascular health, including heart disease and stroke, is essential to reducing health inequities in Black and Hispanic communities, those that have been historically marginalized and under-resourced, and communities that have the highest levels of exposure to air pollution.   

The investigators recommended additional research about the possible interactive effects of extreme weather events and fine particulate pollution on heart attack deaths in areas with different temperature and pollution ranges to confirm their findings. The study did not include adjustments for any adaptive behaviors taken by individuals, such as using air conditioning and staying indoors, when temperatures are extreme or pollution levels are high, which could cause misclassification of individuals’ exposure to weather and alter their risk patterns. These results also may not be generalizable to other regions in China or other countries due to potential variations of adaption capacity and temperature distribution.

Background:

• Fine particulates are less than 2.5 microns in size and may be inhaled deep into the lungs, where they can irritate the lungs and blood vessels around the heart. Most are associated with fuel combustion, such as particles from car exhaust, factory emissions or wildfires.
• Previous research has confirmed that exposure to particulate matter including fine particulates is linked to heart disease, stroke and other health issues.
• For context, the World Health Organization’s target for average annual exposure to fine particulate pollution level is no more than 5 micrograms per cubic meter and no more than 15 micrograms per cubic meter for more than 3-4 days per year.
• In this study, heat waves were defined as periods at or above the 90^th, 92.5^th, 95^th and 97.5^th percentiles of daily heat indexes (ranging from 82.6 to 109.4 degrees Fahrenheit across Jiangsu province, China) for at least 2, 3 or 4 consecutive days.
• Cold spells were defined as periods at or below the 10^th, 7.5^th, 5^th, 2.5^th percentiles of daily heat indexes (ranging from 27 to 40.5 degrees Fahrenheit) for at least 2, 3 or 4 consecutive days.

Co-authors and authors’ disclosures are listed in the manuscript. This study was funded by China’s Ministry of Science and Technology.

Statements and conclusions of studies published in the American Heart Association’s scientific journals are solely those of the study authors and do not necessarily reflect the Association’s policy or position. The Association makes no representation or guarantee as to their accuracy or reliability. The Association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and biotech companies, device manufacturers and health insurance providers and the Association’s overall financial information are available here.

Additional Resources:

• Multimedia is available on right column of release link: https://newsroom.heart.org/news/risk-of-fatal-heart-attack-may-double-in-heat-wave-high-fine-particulate-pollution-days?preview=9b7bae1b67013ad8887edce8c3df94fa
• After July 24, 2023, view the manuscript online.
• AHA news release: Extremely hot and cold days linked to cardiovascular deaths (December 2022)
• AHA news release: Personal protection and public policy change can decrease health impact of pollution (Nov. 2020)
• Follow AHA/ASA news on Twitter @HeartNews
• Follow news from the AHA’s flagship journal Circulation @CircAHA

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