UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  SCHEDULE 13D
                   Under the Securities Exchange Act of 1934
                                (Amendment No.)*


                              ANTARES PHARMA, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, par value $0.01 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   036642106
--------------------------------------------------------------------------------
                                 (CUSIP Number)
Mitchell D. Kaye, Manager                           with a copy to:
Brown Simpson Asset Management, LLC                 Robert G. Minion, Esq.
152 West 57 Street                                  Lowenstein Sandler PC
21st Floor                                          65 Livingston Avenue
New York, New York  10019                           Roseland, New Jersey  07068
(212) 247-8200                                      (973) 597-2424
--------------------------------------------------------------------------------
                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                  July 8, 2003
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule l3G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of ss.ss. 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the
following box. |_|

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including all  exhibits.  See ss.  240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




Cusip No.         036642106
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1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons
   (entities only):
                       Brown Simpson Asset Management, LLC
                               13-3954392
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2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a) Not
         (b) Applicable
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3.  SEC Use Only
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4.  Source of Funds (See Instructions):  WC
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5.  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d)
    or 2(e): Not Applicable
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6.  Citizenship or Place of Organization: New York, United States

    Number of                      7. Sole Voting Power:                  *
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                *
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:             *
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:          *
                                      ------------------------------------------
--------------------------------------------------------------------------------
11. Aggregate Amount Beneficially Owned by Each Reporting Person:  1,417,961*
--------------------------------------------------------------------------------
12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares
    (See Instructions):                               Not Applicable
--------------------------------------------------------------------------------
13. Percent of Class Represented by Amount in Row (11): 9.99%*
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14. Type of Reporting Person (See Instructions): IA
______________________
* Xmark Fund, L.P., a Delaware limited  partnership  ("Xmark LP"), is the holder
of (i) 323,256  shares of Common  Stock,  par value $0.01 per share (the "Common
Stock"), of Antares Pharma,  Inc., a Minnesota  corporation (the "Company") (the
"Xmark LP Shares"),  (ii) an aggregate  of  approximately  $285,217 in principal
amount of 8% Senior  Secured  Convertible  Debentures,  due March 31,  2004 (the
"Xmark LP Debentures"), the outstanding principal and accrued interest of which,
subject to certain restrictions  contained therein, may be converted into Common
Stock  at a  conversion  price of $0.50  per  share  (the  "Xmark  LP  Debenture
Conversion  Shares"),  which  conversion  price is subject to  adjustment as set
forth  in the  Xmark  LP  Debentures,  (iii)  warrants  (the  "Initial  Xmark LP
Warrants") which,  subject to certain exercise  restrictions  contained therein,
entitle  Xmark LP to purchase  up to an  aggregate  of 569,325  shares of Common
Stock at an  exercise  price of $0.55 per share (the  "Initial  Xmark LP Warrant
Shares"), which such exercise price is subject to adjustment as set forth in the
Initial  Xmark LP Warrants;  and (iv)  warrants  (the "2003 Xmark LP  Warrants")
which, subject to certain exercise restrictions contained therein, entitle Xmark
LP to  purchase  an  aggregate  of up to  238,125  shares of Common  Stock at an
exercise  price of $1.25 per share (the "2003 Xmark LP Warrant  Shares"),  which
such  exercise  price is subject to adjustment as set forth in the 2003 Xmark LP
Warrant.  Xmark Fund, Ltd. a Cayman Islands  exempted  company ("Xmark Ltd"), is
the holder of (i) 694,744  shares of Common  Stock (the "Xmark Ltd  Shares," and
together  with  the  Xmark  LP  Shares,  the  "Shares"),  (ii) an  aggregate  of
approximately  $858,524 in  principal  amount of 8% Senior  Secured  Convertible
Debentures,  due March 31, 2004 (the "Xmark Ltd Debentures,"  and, together with



the Xmark LP  Debentures,  the  "Debentures"),  the  outstanding  principal  and
accrued interest of which,  subject to certain  restrictions  contained therein,
may be converted into Common Stock at a conversion price of $0.50 per share (the
"Xmark  Ltd  Debenture  Conversion  Shares,"  and,  together  with the  Xmark LP
Debenture Conversion Shares, the "Conversion Shares"), which conversion price is
subject to adjustment as set forth in the Xmark Ltd  Debentures,  (iii) warrants
(the  "Initial  Xmark Ltd  Warrants,"  and  together  with the Initial  Xmark LP
Warrants,   the  "Initial   Warrants")   which,   subject  to  certain  exercise
restrictions contained therein, entitle Xmark Ltd to purchase an aggregate of up
to 1,680,675 shares of Common Stock at an exercise price of $0.55 per share (the
"Initial  Xmark Ltd Warrant  Shares,"  and,  together  with the Initial Xmark LP
Warrant  Shares,  the "Initial  Warrant  Shares"),  which such exercise price is
subject to adjustment  as set forth in the Initial Xmark Ltd Warrants,  and (iv)
warrants  (the "2003 Xmark Ltd  Warrant,"  and  together  with the 2003 Xmark LP
Warrant and the Initial  Warrants,  the  "Warrants")  which,  subject to certain
exercise  restrictions  contained  therein,  entitle  Xmark Ltd to  purchase  an
aggregate of up to 511,875  shares of Common Stock at an exercise price of $1.25
per share (the "2003 Xmark Ltd Warrant  Shares,"  and together the 2003 Xmark LP
Warrant Shares and the Initial Warrant Shares, the "Warrant Shares"), which such
exercise  price is  subject  to  adjustment  as set forth in the 2003  Xmark Ltd
Warrant.  The Debentures and the Warrants each contain  provisions which provide
that in no event  shall  the  Debentures  be  convertible,  or the  Warrants  be
exercisable, to the extent that the issuance of Conversion Shares and/or Warrant
Shares  thereunder,  taking  into  account  the  Shares,  would  result  in  the
"beneficial  ownership" (as defined in Section 13(d) of the Securities  Exchange
Act of 1934, as amended,  as  Regulations  13D-G  thereunder) by Xmark LP, Xmark
Ltd, or their affiliates,  of more than 9.99% of the Common Stock (the "Issuance
Limitation").  Such Issuance  Limitation  may be waived by Xmark LP and/or Xmark
Ltd upon 61 days notice to the  Company.  As of the date hereof,  such  Issuance
Limitation has not been waived. Brown Simpson Asset Management,  LLC, a New York
limited  liability  company  ("BSAM")  holds 50,000 shares of Common Stock and a
warrant (the "Advisor Warrant") to purchase up to 300,000 shares of Common Stock
at an exercise price of $0.55 per share, which such exercise price is subject to
adjustment  as set forth in the  Advisor  Warrant.  BSAM  serves  as  investment
manager for each of Xmark LP and Xmark Ltd. In such capacity, BSAM possesses the
power to vote and direct the disposition of all securities held by Xmark Fund LP
and Xmark Fund Ltd. Thus, as of July 8, 2003,  for the purposes of Reg.  Section
240.13d-3,  BSAM may be deemed to  beneficially  own 1,147,961  shares of Common
Stock,  or 9.99% of the Common Stock deemed  issued and  outstanding  as of that
date.




Item 1.  Security and Issuer.
         -------------------

     This statement  relates to the common stock,  par value $0.01 per share, of
Antares Pharma, Inc., a Minnesota  corporation (the "Company").  The Company has
principal  executive  offices  located at 707  Eagleview  Boulevard,  Suite 414,
Exton, Pennsylvania 19314.

Item 2.  Identity and Background.
         -----------------------

     The person filing this statement is Brown Simpson Asset Management,  LLC, a
New York limited liability company ("BSAM"). The business address of BSAM is 152
West 57th Street, 21st Floor, New York, New York 10019.

     BSAM serves as the  investment  manager for Xmark  Fund,  L.P.,  a Delaware
limited  partnership  ("Xmark LP"),  Xmark Fund,  Ltd., a Cayman  Islands exempt
company  ("Xmark Ltd") as well as various other  private  investment  funds (the
"Funds").  Xmark LP,  Xmark Ltd and the Funds are engaged in the  investment  in
personal  property of all kinds,  including  but not  limited to capital  stock,
depository  receipts,   investment  companies,   mutual  funds,   subscriptions,
warrants,  bonds,  notes,  debentures,  options and other securities of whatever
kind and nature.

     Mitchell  D.  Kaye,  whose   business   address  is c/o Brown Simpson Asset
Management,  LLC, 152 West 57th Street, 21st Floor, New York, New York 10019, is
the Chief Investment Officer of Xmark LP and Xmark Ltd and the Manager of BSAM.

     BSAM has never been convicted in any criminal proceeding (excluding traffic
violations  or  similar  misdemeanors),  nor has he been a  party  to any  civil
proceeding  commenced  before a judicial  or  administrative  body of  competent
jurisdiction as a result of which he was or is now subject to a judgment, decree
or final order  enjoining  future  violations  of, or  prohibiting  or mandating
activities subject to, federal or state securities laws or finding any violation
with respect to such laws. BSAM is a New York limited liability company.

     Mr. Kaye has never been  convicted  in any criminal  proceeding  (excluding
traffic  violations  or  similar  misdemeanors),  nor has he been a party to any
civil proceeding commenced before a judicial or administrative body of competent
jurisdiction as a result of which he was or is now subject to a judgment, decree
or final order  enjoining  future  violations  of, or  prohibiting  or mandating
activities subject to, federal or state securities laws or finding any violation
with respect to such laws. Mr. Kaye is a citizen of the United States.

Item 3.  Source and Amount of Funds or Other Consideration.
         -------------------------------------------------

     Pursuant to a Securities Purchase  Agreement,  dated as of July 12, 2002 by
and among the Company,  Xmark LP, Xmark Ltd and certain  other  parties  thereto
(the "2002  Purchase  Agreement"),  (i) on July 12,  2002 Xmark LP and Xmark Ltd
purchased $40,827.50 and $134,172.50,  respectively,  in principal amount of the
Company's  10% Secured  Convertible  Debentures,  due July 3, 2003 (the "Initial
2002  Debentures"),  (ii) on July 26, 2002 Xmark LP and Xmark Ltd  purchased  an
additional $40,827.50 and $134,172.50,  respectively, in principal amount of the
Company's 10% Secured Convertible Debentures, due July 26, 2003 (the "Additional
2002  Debentures");  and  (iii) on  October  15,  2002  Xmark LP and  Xmark  Ltd
purchased  $34,995  and  $115,005,  respectively,  in  principal  amount  of the



Company's 10% Secured Convertible Debentures, due October 15, 2003 (the "October
2002  Debentures,"  and  together  with the  Initial  2002  Debentures,  and the
Additional  2002  Debentures,   the  "2002  Debentures").   Subject  to  certain
restrictions  contained  in  the  2002  Debentures,  the  holders  of  the  2002
Debentures had the right, at any time, to convert principal and accrued interest
on the 2002 Debentures into Common Stock.  The 2002 Debentures were  convertible
into shares of Common Stock at a  conversion  price per share equal to the lower
of $2.50 or 75% of the average of the three lowest intraday prices of the Common
Stock, as reported on the Nasdaq SmallCap Market. All funds used by Xmark LP and
Xmark Ltd to purchase  or acquire the 2002  Debentures  came  directly  from the
assets of Xmark LP and Xmark Ltd, respectively.  As described below in this Item
3, the 2002 Debentures are no longer outstanding.

     On January 24, 2003 and January 31, 2003, Xmark LP and Xmark Ltd loaned the
Company an aggregate of approximately  $163,267, and $457,757  respectively.  In
exchange  for such loans,  the Company  issued  Xmark LP and Xmark Ltd 30-day 8%
promissory  notes in  aggregate  principal  amount  of  $163,267,  and  $457,757
respectively (the "Promissory  Notes"). All funds used by Xmark LP and Xmark Ltd
to purchase or acquire the  Promissory  Notes came  directly  from the assets of
Xmark LP and Xmark Ltd,  respectively.  As  described  below in this Item 3, the
Promissory Notes are no longer outstanding.

     Pursuant  to an  Advisory  Agreement,  dated as of January  15, 2003 by and
between BSAM and the Company  (the  "Advisory  Agreement"),  BSAM was issued (i)
50,000  shares of  restricted  Common  Stock and (ii)  warrants  (the  "Advisory
Warrant") to purchase,  at any time after the  issuance  thereof,  up to 300,000
shares of Common  Stock at an  exercise  price of $0.55  per share  (which  such
exercise  price is subject to adjustment as set forth in the Advisory  Warrant).
Such 50,000 shares of Common Stock and Advisory  Warrant were issued pursuant to
the terms of the Advisory Agreement and not for additional cash consideration.

     Pursuant to a  Debenture  and  Warrant  Agreement,  dated as of January 31,
2003, by and among the Company, Xmark LP, and Xmark Ltd (the "Debenture Purchase
Agreement"),  in  consideration  for the surrender of the Promissory  Notes, (i)
Xmark LP was issued (A) an 8% Senior Secured  Convertible  Debenture,  due March
31, 2004, in principal  amount of $163,267.45 (the "Xmark LP Debenture") and (B)
a warrant (the  "Initial  Xmark LP Warrant") to purchase,  at any time after the
issuance  thereof,  subject to certain  restrictions  contained  therein,  up to
394,350  shares of Common Stock,  at an exercise price of $0.55 per share (which
exercise  price is subject to  adjustment  as set forth in the Initial  Xmark LP
Warrant),  and (ii) Xmark Ltd was issued  (A) an 8% Senior  Secured  Convertible
Debenture,  due March 31, 2004, in principal  amount of $457,757.47  (the "Xmark
Ltd Debenture," and together with the Xmark LP Debenture,  the "Debentures") and
(B) a warrant (the  "Initial  Xmark Ltd  Warrant," and together with the Initial
Xmark LP Warrant,  the "Initial  Warrants")  to purchase,  at any time after the
issuance  thereof,  subject to certain  restrictions  contained  therein,  up to
1,105,650 shares of Common Stock, at an exercise price of $0.55 per share (which
exercise  price is subject to  adjustment  as set forth in the Initial Xmark Ltd
Warrant). Subject to certain restrictions contained in the Debentures, principal
and accrued  interest on the Debentures can be converted,  at any time after the
issuance  thereof,  into Common Stock at a  conversion  price of $0.50 per share
(which   conversion  price  is  subject  to  adjustment  as  set  forth  in  the
Debentures).  Xmark LP and Xmark Ltd  acquired  the  Debentures  and the Initial
Warrants in consideration for surrender of the Promissory Notes.



     Pursuant to a separate  Debenture and Warrant  Agreement,  also dated as of
January 31, 2003,  by and among the  Company,  Xmark LP, Xmark Ltd and the other
parties  named  therein  (the  "Restated  Debenture  Purchase  Agreement"),   in
consideration  for the surrender of the 2002  Debentures  (including all accrued
interest thereon),  (i) Xmark LP was issued (A) an 8% Senior Secured Convertible
Debenture, due March 31, 2004, in principal amount of $121,949.81 (the "Restated
Xmark LP Debenture")  and (B) a warrant (the  "Additional  Xmark LP Warrant") to
purchase,   at  any  time  after  the  issuance  thereof,   subject  to  certain
restrictions  contained  therein,  up to 174,975  shares of Common Stock,  at an
exercise price of $0.55 per share (which exercise price is subject to adjustment
as set forth in the Additional Xmark LP Warrant),  and (ii) Xmark Ltd was issued
(A) an 8% Senior Secured Convertible Debenture, due March 31, 2004, in principal
amount of $400,766.92 (the "Restated Xmark Ltd Debenture," and together with the
Restated Xmark LP Debenture,  the "Restated  Debentures") and (B) a warrant (the
"Additional  Xmark Ltd  Warrant,"  and,  together with the  Additional  Xmark LP
Warrant, the "Additional  Warrants") to purchase, at any time after the issuance
thereof, subject to certain restrictions contained therein, up to 575,025 shares
of Common Stock,  at an exercise price of $0.55 per share (which  exercise price
is subject to  adjustment  as set forth in the  Additional  Xmark Ltd  Warrant).
Subject to certain restrictions contained in the Restated Debentures,  principal
and accrued  interest on the Restated  Debentures can be converted,  at any time
after the issuance thereof, into Common Stock at a conversion price of $0.50 per
share  (which  conversion  price is  subject to  adjustment  as set forth in the
Restated  Debentures).  Xmark LP and Xmark Ltd acquired the Restated  Debentures
and  the  Additional  Warrants  in  consideration  for  surrender  of  the  2002
Debentures.

     Pursuant to a Purchase  Agreement,  dated as of July 7, 2003,  by and among
the  Company,  Xmark LP,  Xmark  Ltd and  certain  other  parties  thereto  (the
"Purchase Agreement"), on July 8, 2003 (i) Xmark LP purchased (A) 317,500 shares
of Common Stock at a price of $1.00 per share, and (B) warrants (the "2003 Xmark
LP Warrants") to purchase up to 238,125  shares of Common Stock,  and (ii) Xmark
Ltd purchased (A) 682,500  shares of Common Stock at a price of $1.00 per share,
and (B) warrants  (the "2003 Xmark Ltd  Warrants,"  and  together  with the 2003
Xmark LP  Warrants,  the "2003  Warrants")  to purchase up to 511,875  shares of
Common Stock.  Subject to certain  restrictions  contained in the 2003 Warrants,
the 2003 Warrants are  exercisable  at any time on or after the date of issuance
thereof into Common Stock.  The exercise price of the 2003 Warrants is $1.25 per
share,  subject to certain  exercise  price  adjustments  contained  in the 2003
Warrants.  All funds used to purchase or acquire the  securities  in  connection
with the Purchase  Agreement came directly from the assets of Xmark LP and Xmark
Ltd.

     The  Debentures,   the  Restated  Debentures,  the  Initial  Warrants,  the
Additional  Warrants  and the 2003  Warrants  each  contain  a  provision  which
provides  that in no event shall the  Debentures  or the Restated  Debentures be
convertible,  or the Initial Warrants,  Additional  Warrants or 2003 Warrants be
exercisable,  to the  extent  that  the  issuance  of  Common  Stock  upon  such
conversion  and/or  exercise,  would result in the  "beneficial  ownership"  (as
defined in Section 13(d) of the Securities  Exchange Act of 1934, as amended, as
Regulations  13D-G  thereunder) by Xmark LP, Xmark Ltd or their  affiliates,  of
more than 9.99% of the Common Stock (the "Issuance  Limitation").  Such Issuance
Limitation may be waived by Xmark LP and/or Xmark Ltd upon 61 days notice to the
Company. As of the date hereof, such Issuance Limitation has not been waived.



Item 4.   Purpose of Transaction.
          ----------------------

     The  acquisition  of the  securities  referred to herein is for  investment
purposes.  Pursuant to the terms of the  Purchase  Agreement,  Xmark Fund LP and
Xmark Fund Ltd have the right to designate one (1) person for  nomination to the
Company's Board of Directors (the  "Designee").  In connection with the Purchase
Agreement, the Company, Xmark LP, Xmark Ltd, Dr. Jacques Gonella (a director and
principal  shareholder  of the Company) and  Permatech  Holdings AG (a principal
shareholder of the Company) entered into a Voting Agreement, dated as of July 7,
2003 (the "Voting  Agreement")  pursuant to which the Company,  Dr.  Gonella and
Permatech  Holdings AG agreed,  among other things,  to take all actions  within
their  receptive  control to ensure the  nomination and election to the Board of
Directors of the Designee.

     Other than as set forth above in this Item 4, BSAM has no present  plans or
intentions which relate to or would result in any of the  transactions  required
to be described in Item 4 of Schedule 13D.

Item 5. Interest in Securities of the Issuer.
        ------------------------------------

     Based upon  information  provided by the  Company,  taking into account the
sales of Common  Stock in  connection  with the Purchase  Agreement,  there were
14,193,805  shares of Common Stock issued and outstanding as of July 8, 2003. As
of July 8, 2003,  Xmark LP and Xmark Ltd own, in aggregate,  1,018,000 shares of
Common  Stock.  As of July 8, 2003,  BSAM owns 50,000 shares of Common Stock and
warrants to acquire  300,000 shares of Common Stock. As a result of the Issuance
Limitation,  the Debentures,  the Restated Debentures, the Initial Warrants, the
Additional  Warrant  and the  2003  Warrants  are,  within  the  next  60  days,
convertible into and/or exercisable for, an aggregate of 49,961 shares of Common
Stock.  BSAM  possesses  sole power to vote and direct  the  disposition  of all
securities  held by Xmark LP and Xmark Ltd.  Thus,  as of July 8, 2003,  for the
purposes of Reg. ss.240.13d-3, BSAM, the investment manager for each of Xmark LP
and Xmark Ltd,  may be deemed to  beneficially  own  1,417,961  shares of Common
Stock,  or 9.99% of the shares of Common Stock deemed issued and  outstanding as
of that date.

     BSAM  expressly  disclaims   beneficial   ownership  of  the  Common  Stock
beneficially owned by the other parties to the Voting Agreement.

     As stated in Item 3 above,  pursuant to the Purchase Agreement,  on July 8,
2003 (i) Xmark LP  purchased  (A) 317,500  shares of Common  Stock at a price of
$1.00 per share,  and (B)  warrants to  purchase up to 238,125  shares of Common
Stock,  and (ii) Xmark Ltd  purchased  (A) 682,500  shares of Common  Stock at a
price of $1.00 per share,  and (B) warrants to purchase up to 511,875  shares of
Common Stock.

     In addition,  the following  table details the  transactions  during the 60
days prior to July 8, 2003 in Common  Stock,  or  securities  convertible  into,
exercisable  for or  exchangeable  for  Common  Stock,  by BSAM or any person or
entity  controlled  by BSAM or any  person or entity  for which  BSAM  possesses
voting or investment  control over the  securities  thereof (each of which , was
effected in an ordinary brokerage transaction):



                                   I. Xmark LP
                                  (Purchases)

     Date                          Quantity                Price Per Share

  June 5, 2003                      12,792                       $0.9844

                                    (Sales)

     Date                           Quantity               Price Per Share

  June 16, 2003                      1,600                       $1.6501
  June 17, 2003                      5,436                       $1.7084


                                  II. Xmark Ltd

                                  (Purchases)

     Date                           Quantity               Price Per Share

  June 5, 2003                      27,208                       $0.9844

                                    (Sales)
       -                               -                            -
     Date                           Quantity               Price Per Share

  June 16, 2003                      3,400                       $1.6501
  June 17, 2003                     11,565                       $1.7084

Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to
        Securities of the Issuer.
        ------------------------------------------------------------------------

     In connection with the purchase of the 2002 Debentures,  in addition to the
2002 Purchase Agreement,  Xmark LP and Xmark Ltd entered into (i) a Registration
Rights Agreement,  dated July 12, 2002,  pursuant to which,  among other things,
the Company,  Xmark Fund LP, Xmark Fund Ltd and certain other parties  agreed to
the terms  pursuant to which the Company agreed to register the shares of Common
Stock issuable upon  conversion of the 2002  Debentures for resale by the filing
of a registration statement with the Securities and Exchange Commission pursuant
to the  Securities  Act of 1933,  as amended,  as well as perform  various other
obligations  and agreements  related to such  registration,  and (ii) a Security
Agreement,  dated July 12, 2002 (the "Initial Security Agreement"),  pursuant to
which,  among other  things,  the Company  granted the parties  named  therein a
security  interest in  substantially  all of the assets of the Company to secure
the Company's  payment  obligations  under the debentures issued pursuant to the
2002 Purchase Agreement.  In addition,  the Company issued to Xmark LP and Xmark
Ltd the 2002 Debentures.

     In  connection  with  the  purchase  of the  Debentures  and  the  Restated
Debentures,  in addition to the  Debenture  Purchase  Agreement and the Restated
Debenture  Purchase  Agreement,  Xmark  LP and  Xmark  Ltd  entered  into  (i) a
Registration Rights Agreement,  dated January 31, 2003, pursuant to which, among



other  things,  the  Company,  Xmark Fund LP,  Xmark Fund Ltd and certain  other
parties agreed to the terms pursuant to which the Company agreed to register the
shares of Common  Stock  issuable  upon  conversion  of the  Debentures  and the
Restated  Debentures,  and the shares of Common Stock  issuable upon exercise of
the Initial Warrants and the Additional Warrants,  for resale by the filing of a
registration  statement with the Securities and Exchange  Commission pursuant to
the  Securities  Act of 1933,  as  amended,  as well as  perform  various  other
obligations and agreements related to such registration, and (ii) an Amended and
Restated  Security  Agreement,  dated  January 31,  2003,  which such  agreement
amended and restated to Initial  Security  Agreement,  pursuant to which,  among
other things,  the Company granted the parties named therein a security interest
in  substantially  all of the  assets of the  Company  to secure  the  Company's
payment  obligations  under the  debentures  issued  pursuant  to the  Debenture
Purchase Agreement and the Restated Debenture Purchase  Agreement.  In addition,
the  Company  issued  to Xmark LP and  Xmark Ltd the  Debentures,  the  Restated
Debentures, the Initial Warrants and the Additional Warrants.

     In  addition,  pursuant  to the  terms  of each of the  Debenture  Purchase
Agreement and the Restated Debenture Agreement,  the Company agreed, among other
things,  to (i) solicit proxies from the  shareholders of the Company to vote in
favor of the approval of the issuance of shares of Common  Stock  issuable  upon
conversion of the Debentures and the Restated  Debentures in connection with the
transactions  contemplated by the Debenture  Purchase Agreement and the Restated
Debenture Purchase Agreement, greater in the aggregate than 19.99% of the number
of  shares  of  Common  Stock  outstanding  prior  to  the  consummation  of the
transactions  contemplated by the Debenture  Purchase Agreement and the Restated
Debenture  Purchase  Agreement  and (ii)  cause  the board of  directors  of the
Company to  recommend  to the  stockholders  that they  approve  such  proposal.
Additionally,  the Company granted each of the parties to the Debenture Purchase
Agreement and the Restated Debenture Purchase Agreement, the right, for a period
expiring on January  31,  2005,  to  participate  (as a  purchaser  and not as a
seller)  in any  proposed  sale by the  Company of any  equity  security  or any
security which is convertible into or exercisable for any equity security.

     In  connection  with  the  Advisory  Agreement,  BSAM  agreed  to  act as a
non-exclusive  financial  advisor  to the  Company.  The  term  of the  Advisory
Agreement  commenced on January 15, 2003 and the  agreement may be terminated by
either party for any reason upon 10 days advance written  notice.  In connection
with the Advisory Agreement,  BSAM was issued 50,000 shares of restricted Common
Stock and the Advisory  Warrant.  In addition,  the Company  agreed to reimburse
BSAM  for  reasonable  out-of-pocket  expenses  incurred  by BSAM  in  providing
services under the Advisory  Agreement and,  subject to certain  exceptions,  to
indemnify BSAM and its affiliates in connection with services provided under the
Advisory Agreement.

     In connection with the purchase of the 1,000,000 shares of Common Stock and
the 2003 Warrants, in addition to the Purchase Agreement, Xmark LP and Xmark Ltd
entered into (i) a Registration  Rights Agreement,  dated July 7, 2003, pursuant
to which,  among other  things,  the Company,  Xmark Fund LP, Xmark Fund Ltd and
certain other parties  agreed to the terms  pursuant to which the Company agreed
to register the shares of Common Stock  purchased  under the Purchase  Agreement
and the shares of Common Stock issuable upon conversion of the 2003 Warrants for
resale  by the  filing  of a  registration  statement  with the  Securities  and
Exchange  Commission pursuant to the Securities Act of 1933, as amended, as well



as  perform   various  other   obligations   and  agreements   related  to  such
registration,  and (ii) the Voting  Agreement,  pursuant  to which,  among other
things,  the Company,  Dr. Gonella and Permatech  Holdings AG agreed to take all
actions within their receptive  control to ensure the nomination and election to
the Board of Directors of the Designee. In addition, the Company issued to Xmark
LP and  Xmark  Ltd  the  2003  Warrants.  BSAM  expressly  disclaims  beneficial
ownership of the Common  Stock  beneficially  owned by the other  parties to the
Voting Agreement.

     The  descriptions  of the  transactions  and  agreements  set forth in this
Schedule  13D are  qualified  in their  entirety by  reference  to the  complete
agreements  governing such matters,  each of which are incorporated by reference
to this Schedule 13D as exhibits pursuant to Item 7 hereof.

     Except  as  otherwise   described  herein,   no  contracts,   arrangements,
understandings or similar  relationships exist with respect to the securities of
the Company between BSAM and any person or entity.

Item 7.  Material to be Filed as Exhibits.
         --------------------------------

          1. Securities  Purchase  Agreement,  dated as of July 12, 2002,  among
Antares  Pharma,  Inc.,  Xmark Fund,  LP, Xmark Fund,  Ltd.,  and certain  other
parties  identified  therein,  incorporated by reference to Exhibit 10.29 to the
Current Report on Form 8-K, dated July 17, 2002, filed by Antares Pharma, Inc.

          2.  Registration  Rights  Agreement,  dated as of July 12, 2002, among
Antares  Pharma,  Inc.,  Xmark Fund,  LP, Xmark Fund,  Ltd.,  and certain  other
parties  identified  therein,  incorporated by reference to Exhibit 10.30 to the
Current Report on Form 8-K, dated July 17, 2002, filed by Antares Pharma, Inc.

          3.  Security  Agreement,  dated as of July  12,  2002,  among  Antares
Pharma,  Inc.,  Xmark Fund,  LP, Xmark Fund,  Ltd.,  and certain  other  parties
identified  therein,  incorporated  by reference to Exhibit 10.31 to the Current
Report on Form 8-K, dated July 17, 2002, filed by Antares Pharma, Inc.

          4. Form of Secured Convertible Debenture,  dated July 12, 2002, issued
by Antares Pharma, Inc. to Xmark Fund, LP and Xmark Fund, Ltd.,  incorporated by
reference  to Exhibit  10.32 to the Current  Report on Form 8-K,  dated July 17,
2002, filed by Antares Pharma, Inc.

          5. Debenture and Warrant Purchase  Agreement,  dated as of January 31,
2003, among Antares Pharma,  Inc., Xmark Fund, LP, Xmark Fund, Ltd., and certain
other parties identified therein,  incorporated by reference to Exhibit 10.39 to
the  Current  Report on Form 8-K,  dated  February  12,  2003,  filed by Antares
Pharma, Inc.

          6. Debenture and Warrant Purchase  Agreement,  dated as of January 31,
2003,  among  Antares  Pharma,  Inc.,  Xmark  Fund,  LP, and Xmark  Fund,  Ltd.,
incorporated  by reference to Exhibit  10.40 to the Current  Report on Form 8-K,
dated February 12, 2003, filed by Antares Pharma, Inc.



          7. Registration Rights Agreement,  dated as of January 31, 2003, among
Antares  Pharma,  Inc.,  Xmark Fund,  LP, Xmark Fund,  Ltd.,  and certain  other
parties  identified  therein,  incorporated by reference to Exhibit 10.41 to the
Current Report on Form 8-K, dated  February 12, 2003,  filed by Antares  Pharma,
Inc.

          8. Amended and Restated  Security  Agreement,  dated as of January 31,
2003, among Antares Pharma,  Inc., Xmark Fund, LP, Xmark Fund, Ltd., and certain
other parties identified therein,  incorporated by reference to Exhibit 10.42 to
the  Current  Report on Form 8-K,  dated  February  12,  2003,  filed by Antares
Pharma, Inc.

          9. Form of Warrants, dated January 31, 2003, issued by Antares Pharma,
Inc. to each of Xmark Fund, L.P. and Xmark Fund, Ltd., incorporated by reference
to Exhibit  10.43 to the Current  Report on Form 8-K,  dated  February 12, 2003,
filed by Antares Pharma, Inc.

          10 Form of 8% Senior Secured Convertible Debentures, dated January 31,
2003, issued by Antares Pharma, Inc. to each of Xmark Fund, L.P. and Xmark Fund,
Ltd.,  incorporated  by reference to Exhibit 10.44 to the Current Report on Form
8-K, dated February 12, 2003, filed by Antares Pharma, Inc.

          11.  Form of  Amended  and  Restated  8%  Senior  Secured  Convertible
Debentures,  dated January 31, 2003,  issued by Antares Pharma,  Inc. to each of
Xmark Fund,  L.P.  and Xmark Fund,  Ltd.,  incorporated  by reference to Exhibit
10.45 to the Current  Report on Form 8-K,  dated  February  12,  2003,  filed by
Antares Pharma, Inc.

          12. Form of Promissory Notes,  dated January 24, 2003, and January 31,
2003, issued by Antares Pharma, Inc. to each of Xmark Fund, L.P. and Xmark Fund,
Ltd.,  incorporated  by reference to Exhibit 10.46 to the Current Report on Form
8-K, dated February 12, 2003, filed by Antares Pharma, Inc.

          13.  Purchase  Agreement,  dated  as of July 7,  2003,  among  Antares
Pharma,  Inc.,  Xmark Fund,  LP, Xmark Fund,  Ltd.,  and certain  other  parties
identified  therein,  incorporated  by reference to Exhibit 10.48 to the Current
Report on Form 8-K, dated July 9, 2003, filed by Antares Pharma, Inc.

          14.  Registration  Rights  Agreement,  dated as of July 7, 2003, among
Antares  Pharma,  Inc.,  Xmark Fund,  LP, Xmark Fund,  Ltd.,  and certain  other
parties  identified  therein,  incorporated by reference to Exhibit 10.49 to the
Current Report on Form 8-K, dated July 9, 2003, filed by Antares Pharma, Inc.

          15. Voting Agreement,  dated as of July 9, 2003, among Antares Pharma,
Inc., Xmark Fund, LP, Xmark Fund, Ltd., Dr. Jacques Gonella and Permatec Holding
AG,  incorporated  by reference to Exhibit  10.50 to the Current  Report on Form
8-K, dated July 7, 2003, filed by Antares Pharma, Inc.

          16.  Form of  Warrants,  dated  January  31,  2003,  issued by Antares
Pharma,  Inc. to each of Xmark Fund, L.P. and Xmark Fund, Ltd.,  incorporated by
reference  to Exhibit  10.51 to the  Current  Report on Form 8-K,  dated July 9,
2003, filed by Antares Pharma, Inc.



                                   Signature

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                                            July 18, 2003

                                            BROWN SIMPSON ASSET MANAGEMENT, LLC

                                            /s/ Mitchell D. Kaye
                                            ------------------------------------
                                            Mitchell D. Kaye, Manager


Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
criminal violations (See 18 U.S.C. 1001).