UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   Form 10-K/A
                          Amendment No. 1 to Form 10-K
              ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

                   For the fiscal year ended December 31, 2000

                           Commission File No. 0-20139

                                  Diacrin, Inc.
             (Exact name of registrant as specified in its charter)

            Delaware                                            22-3016912
(State or other jurisdiction of                             (I.R.S. Employer
incorporation or organization)                              Identification No.)

      Building 96 13th  Street,  Charlestown  Navy Yard,  Charlestown,  MA 02129
          (Address of principal executive offices, including zip code)

                                 (617) 242-9100
              (Registrant's telephone number, including area code)

          Securities registered pursuant to Section 12 (b) of the Act:
   Title of each class             Name of each exchange on which registered
         None                                         None

          Securities registered pursuant to Section 12 (g) of the Act:
                               Title of each class
                          Common Stock, $.01 par value

     Indicate by check mark  whether the  registrant:  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days. YES  X    NO     .
                                              ----    -----

         Indicate by check mark if disclosure of delinquent  filers  pursuant to
Item 405 of Regulation S-K is not contained  herein,  and will not be contained,
to the best of  registrant's  knowledge,  in  definitive  proxy  or  information
statements  incorporated  by  reference  in Part  III of this  Form  10-K or any
amendment to this Form 10-K. []

         The  approximate  aggregate  market  value of the voting  stock held by
non-affiliates of the registrant (based on the closing price of the Common Stock
on February 28, 2001) was $48,008,297.

         As of February 28, 2001,  17,914,704 shares of the registrant's  Common
Stock were outstanding.






This  Amendment No. 1 on Form 10-K/A to the  Registrant's  Annual Report on Form
10-K for the year ended  December 31, 2000 (the  "Report") is being filed to add
the information required to be set forth in Part III of the Report.

                                    PART III

Item 10. Directors and Executive Officers of the Registrant

         Information  regarding  executive officers and directors of the company
is  furnished  in Part I of this  Annual  Report on Form 10-K under the  heading
"Executive Officers of the Registrant."

Section 16(a) Beneficial Ownership Reporting Compliance

         Section 16(a) of the  Securities  Exchange Act of 1934, as amended (the
"Exchange  Act"),  requires the  Diacrin,  Inc.'s (the  "Company's")  directors,
executive  officers  and persons  who own more than ten percent of a  registered
class  of the  Company's  equity  securities  to file  with the  Securities  and
Exchange  Commission  initial  reports of  ownership  and  reports of changes in
ownership of Common Stock and other equity securities of the Company.  Officers,
directors and greater than ten percent beneficial owners are required to furnish
the Company with copies of all Section 16(a) forms that they file.

         Based  solely on its review of the copies of such  reports  received or
written  representations  that no  other  reports  were  required,  the  Company
believes  that,  during the fiscal year ended  December 31, 2000,  its officers,
directors and  ten-percent  stockholders  complied with all Section 16(a) filing
requirements applicable to such individuals.

Item 11. Executive Compensation

         Summary  Compensation  Table.  The  following  table sets forth certain
information  with respect to the annual and long-term  compensation  for each of
the last three fiscal years of the Company's Chief  Executive  Officer and Chief
Operating Officer (the "Named Officers"):




                                      Annual Compensation          Long-Term Compensation
                                                                            Awards
           Name and                                                 Securities Underlying
     Principal Position       Year    Salary($)(1)     Bonus($)(2)         Options(#)
                                                              
Thomas H. Fraser              2000      $270,000       $25,000             25,000
   President and Chief        1999       260,000        40,000             25,000
   Executive Officer          1998       250,000        35,000             25,000

E. Michael Egan               2000      $200,000       $20,000             20,000
   Chief Operating Officer    1999       190,000        30,000             20,000
                              1998       180,000        25,000             20,000



------------------------------
(1)  Amounts  shown include cash  compensation  earned and received by the Named
     Officers as well as amounts  earned but  deferred at the  election of these
     officers to the Company's 401(k) Plan.

(2)  Amounts in this column  represent  bonuses paid or accrued under the annual
     management bonus plan.





Option  Grants  Table.  The  following  table  sets  forth  certain  information
regarding  options granted during the fiscal year ended December 31, 2000 to the
Named Officers:





                                              Individual Grants
                    -----------------------------------------------------------
                                     Percent of                                     Potential Realizable Value
                     Number of          Total                                        at Assumed Annual Rates
                    Securities         Options                                     of Stock Price Appreciation
                    Underlying        Granted to     Exercise or                       for Option Term (2)
                      Options        Employees in     Base Price     Expiration    ----------------------------
      Name        Granted (#) (1)     Fiscal Year       ($/Sh)          Date          5% ($)         10% ($)
      ----        ---------------     -----------    -----------      ---------    ------------  --------------
                                                                                 
Thomas H. Fraser       25,000             16%           $4.69         12/27/10       $73,705       $186,785
E. Michael Egan        20,000             13%           $4.69         12/27/10       $58,964       $149,428




---------------
(1)  Options   granted  in  2000  become   exercisable   in  four  equal  annual
     installments, commencing 12 months after the date of grant.

(2)  Amounts  represent  hypothetical  gains  that  could  be  achieved  for the
     respective  options if exercised at the end of the option term. These gains
     are  based  on  assumed  rates of stock  price  appreciation  of 5% and 10%
     compounded  annually from the date the  respective  options were granted to
     their expiration date. Actual gains, if any, on stock option exercises will
     depend on the future  performance of the Common Stock and the date on which
     the options are exercised.

         Aggregated  Option  Exercises and Year-End Option Table.  The following
table sets forth certain information regarding aggregate option exercises during
the fiscal year ended  December 31, 2000 and the number and value of unexercised
stock options held as of December 31, 2000 by the Named Officers:



                                                                        Number of
                                                                   Securities Underlying       Value of Unexercised In-
                                                                   Unexercised Options at        the-Money Options at
                                                                     Fiscal Year-End (#)        Fiscal Year-End ($)(2)
                       Shares Acquired      Value Realized             Exercisable/                 Exercisable/
    Name                on Exercise (#)        ($)(1)                   Unexercisable                Unexercisable
   ------              ----------------     --------------         -----------------             -----------------
                                                                                       
Thomas H. Fraser                 -                -                 158,750 / 63,750                $299,375 / $7,799
E. Michael Egan                  -                -                 162,495 / 50,000                $395,482 / $6,240



--------------------
(1)  Represents the  difference  between the exercise price and the value of the
     Company's Common Stock on the date of exercise.

(2)  Based on the value of the  Company's  Common  Stock on  December  29,  2000
     ($5.00 per share), the last trading day of 2000, less the applicable option
     exercise price.

Director Compensation

         Dr. Horovitz  receives $2,000 plus expenses per board meeting  attended
plus an additional  $4,000  annually for consulting  work performed on behalf of
the Company.  No other directors  receive any cash  compensation for services on
the Board of Directors.

         On June 19, 2000, all non-employee  directors were granted an option to
purchase 6,000 shares of Common Stock under the Company's 1997 Stock Option Plan
at an  exercise  price of $7.88 per share.  The options  may be  exercised  on a
cumulative basis as to 25% of the shares on the first anniversary of the date of
grant and an additional 25% at the end of each one-year period thereafter.

Employment Agreements

         The Company has entered into a letter  agreement  with Dr. Fraser dated
February 6, 1990, providing for an annual salary plus bonus as determined by the
Board of  Directors.  The Company has agreed with Dr.  Fraser to continue to pay
his then  current  salary  for a  period  of six  months  if it  terminates  his
employment  without  cause.  Dr.  Fraser has also agreed not to compete with the
Company for one year following  termination of his employment.  At the Company's
election,  this  non-competition  provision  can be extended  for an  additional
two-year period upon the payment of additional consideration.

Compensation Committee Interlocks and Insider Participation

         Mr.  Termeer  serves  on  the  Company's  Compensation   Committee.  In
September  1996, the Company formed a joint venture with Genzyme  Corporation to
develop and commercialize the Company's  NeuroCell(TM)-PD  and  NeuroCell(TM)-HD
products for transplantation into patients with advanced Parkinson's disease and
Huntington's  disease,  respectively.  Under  the  terms  of the  joint  venture
agreement which was effective October 1, 1996, Genzyme agreed to provide 100% of
the first $10 million in funding and 75% of the following $40 million in funding
for the  development  and  commercialization  of the  two  products.  All  costs
incurred in excess of $50 million are to be shared  equally  between the Company
and Genzyme in accordance  with the terms of the  agreement.  Any profits of the
joint venture will be shared equally by the two parties.  Mr. Termeer,  a member
of the Company's Board of Directors,  is President,  Chief Executive Officer and
Chairman of the Board of Genzyme.  The Company has recorded  approximately $14.5
million in revenue from the joint  venture  since it  commenced,  $2,081,795  of
which the Company  recognized  during 2000.  Revenues  recognized from the joint
venture and funded by Genzyme in accordance  with the terms of the joint venture
agreement  are  currently  expected to represent a  substantial  majority of the
Company's revenues in 2001.

Item 12. Security Ownership of Certain Beneficial Owners and Management

         The  following  table  sets  forth  the  beneficial  ownership  of  the
Company's Common Stock as of March 31, 2001 by:

     - each person who is known to beneficially own more than 5% of the
       Company's Common Stock;

     - each director or nominee for director of the Company;

     - each executive officer of the Company named in the Summary  Compensation
       Table under the heading "Executive  Compensation"; and

     - all executive officers and directors of the Company as a group.

         Unless  otherwise  noted,  each  person  or group has sole  voting  and
investment power of the shares listed.  The inclusion of any shares listed below
as beneficially  owned does not constitute an admission of beneficial  ownership
of those shares.

         The "Options"  column  reflects  shares of the  Company's  Common Stock
subject to options  which are  exercisable  within 60 days after March 31, 2001.
The shares of the Company's Common Stock which are subject to options are deemed
to be  outstanding  for the purpose of computing the  percentage of ownership of
the  person  holding  such  options,  but are not deemed to be  outstanding  for
computing the percentage of ownership of any other person. As of March 31, 2001,
there were 17,914,704 shares of Common Stock outstanding.







                                                        Number of Shares
                                                       Beneficially Owned              Percentage of
                                                     -----------------------            Common Stock
                  Name and Address                  Shares            Options           Outstanding
                                                                                 
HealthCare Ventures II, L.P. (1)...........       3,196,385             --                 17.8%
HealthCare Ventures III, L.P. (1)..........         994,078             --                  5.5
HealthCare Ventures IV, L.P. (1)...........         291,922             --                  1.6
Rho Management Trust II (2)................       1,592,887             --                  8.9
Hudson Trust (3)...........................       1,342,680             --                  7.5
State of Wisconsin Investment Board (4)....       2,658,200             --                 14.8
Thomas H. Fraser, Ph.D.....................         483,488          158,750                3.6
Zola P. Horovitz, Ph.D. ...................           4,000           19,500                 *
John W. Littlechild (1)....................       4,482,385           11,500               25.1
Stelios Papadopoulos, Ph.D.................         200,000           11,500                1.2
Joshua Ruch (5)............................       1,759,587           11,500                9.9
Henri A. Termeer...........................           7,750           44,500                 *
E. Michael Egan............................           4,169          162,495                1.0
All directors and executive officers as a
group (8 persons)..........................       6,941,379          429,245               40.2



-------------------------------------

*  Less than 1.0%

(1)  John W.  Littlechild is a general  partner of HealthCare  Partners II, L.P.
     ("HCPII"), HealthCare Partners III, L.P. ("HCPIII") and HealthCare Partners
     IV, L.P.  ("HCPIV"),  the general  partner of HealthCare  Ventures II, L.P.
     ("HCVII"), HealthCare Ventures III, L.P. ("HCVIII") and HealthCare Ventures
     IV, L.P. ("HCVIV"),  respectively. Mr. Littlechild,  together with James H.
     Cavanaugh,  Harold R. Werner and William Crouse, the other general partners
     of HCPII,  HCPIII  and HCPIV,  share  voting and  investment  control  with
     respect to shares  owned by HCVII,  HCVIII,  and HCVIV,  respectively.  Mr.
     Littlechild  does not own any shares of the Company's  capital stock in his
     individual  capacity.  The address of  HealthCare  Ventures II, III and IV,
     L.P. is 44 Nassau Street, Princeton, New Jersey 08542.

(2)  Rho Management  Partners,  L.P. may be deemed the beneficial owner of these
     shares  pursuant to an  investment  advisory  agreement  that  confers sole
     voting and investment control over such shares to Rho Management  Partners,
     L.P. The address of Rho Management Trust II is c/o Rho Management  Company,
     Inc., 152 West 57th Street, New York, New York 10019.

(3)  The address of Hudson Trust is c/o Summit Asset  Management  Co.,  Inc., 47
     Hulfish Street, Suite 420, Princeton, New Jersey 08542.

(4)  The address of the State of  Wisconsin  Investment  Board is P.O. Box 7842,
     Madison, Wisconsin 53707.

(5)  Mr. Ruch is a controlling person of Rho Management  Partners,  L.P. and may
     be deemed the beneficial  owner of the shares held by Rho Management  Trust
     II. In addition,  Mr. Ruch exercises  investment and voting  authority over
     166,700  shares  directly  for his own  account,  for the account of family
     members or for the  account of other  clients of Rho  Management  Partners,
     L.P.

Item 13. Certain Relationships and Related Transactions

         HCVII,  HCVIII and HCVIV owned 17.8%,  5.5% and 1.6% or our outstanding
capital stock as of March 31, 2001,  respectively.  HCVII,  HCVIII and HCVIV are
limited  partnerships  which were formed to provide  capital to companies in the
health care fields. HCPII, HCPIII and HCPIV are limited partnerships which serve
as general partner of HCVII, HCVIII and HCVIV, respectively. John Littlechild, a
member of our board of  directors,  is a general  partner  of HCPII,  HCPIII and
HCPIV and Vice Chairman of Healthcare  Vetnures LLC, the management  company for
HCVII,  HCVIII and HCVIV. Mr.  Littlechild is an officer of HealthCare  Ventures
LLC. See "Security Ownership of Certain Beneficial Owners and Management."

         Rho Management  Trust II, which owned 8.9% of our  outstanding  capital
stock as of March 31,  2001,  also  holds  approximately  18.9% and 54.3% of the
outstanding limited partnerships interests in HCVII and HCVIV, respectively.  An
affiliate of Rho is also a limited  partner of HCPII,  HCPIII and HCPIV.  Joshua
Ruch, a member of the board of directors,  is a  controlling  person of Rho. See
"Security Ownership of Certain Beneficial Owners and Management."

         Hudson,  which owned 7.5% of our outstanding  capital stock as of March
31, 2001, also holds  approximately  6.0% and 11.9% of the  outstanding  limited
partnership interests of HCVII and HCVIV, respectively. Hudson is also a limited
partner of HCPII.  See  "Security  Ownership  of Certain  Beneficial  Owners and
Management."

     See "Executive Compensation - Compensation Committee Interlocks and Insider
Participation."

                                   SIGNATURES

                  Pursuant to the requirements of the Securities Exchange Act of
1934,  the  registrant has duly caused this Amendment No. 1 on Form 10-K/A to be
signed on its behalf by the undersigned, thereunto duly authorized.

DIACRIN, INC.


By:       /s/  Thomas H. Fraser
        ------------------------------------
               Thomas H. Fraser
               President and Chief Executive Officer

Date:    April 18, 2001