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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): August 21, 2002

                          BioMarin Pharmaceutical Inc.
             (Exact name of registrant as specified in its charter)


            Delaware                   000-26727                  68-0397820
(State or other jurisdiction of       (Commission               (IRS Employer
 incorporation or organization)       File Number)           Identification No.)


371 Bel Marin Keys Boulevard, Suite 210, Novato, California             94949
(Address of principal executive offices)                              (Zip Code)


Registrant's telephone number, including area code:             (415) 884-6700


                                  Not Applicable
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            (Former name or former address, if changed since last report)
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Item 2.           Acquisition or Disposition of Assets.

     On  August  21,  2002,  BioMarin  Pharmaceutical  Inc.  (the  "Registrant")
completed its acquisition of all of the outstanding  shares of Glyko  Biomedical
Ltd. ("Glyko") pursuant to the Acquisition  Agreement for a Plan of Arrangement,
dated as of February 6, 2002 and as amended by the Amending  Agreement  dated as
of May 16, 2002 (as amended,  the "Agreement"),  among the Registrant,  BioMarin
Acquisition  (Nova Scotia)  Company,  an indirect wholly owned subsidiary of the
Registrant, and Glyko.

     Pursuant to the terms of the  Agreement  each holder of Glyko common shares
received 0.3309 of a share of the Registrant's common stock in exchange for each
Glyko common share held. The Registrant issued approximately, but not more than,
11,367,617  shares of its common  stock in order to  consummate  the exchange of
shares.

     Glyko has no operating  activities or operational  employees.  Glyko's only
significant asset, other than cash, and cash equivalents, is its approximate 21%
ownership interest in the Registrant.

     On August 23, 2002,  the  Registrant  filed with the  Secretary of State of
Delaware a Certificate of Designation  establishing the Series A Preferred Stock
of the Registrant. Following the closing of the acquisition of Glyko, Registrant
exchanged the 11,367,617 shares of its stock owned by Glyko for shares of Series
A Preferred  Stock and cancelled such  11,367,617  shares of common stock.  As a
result of the transaction,  Glyko is now an indirect, wholly owned subsidiary of
BioMarin and the shares of BioMarin  previously held by Glyko have been retired,
with the number of outstanding  shares of BioMarin's  common stock remaining the
same.

     Erich Sager and Gwynn Williams,  directors of the Registrant,  collectively
owned or  controlled  approximately  8.3% of the Glyko common shares and, on the
basis of such holdings, are entitled to beneficially receive approximately 3,309
shares and 942,564 shares of the  Registrant's  common stock,  respectively.  In
addition,  Erich Sager held options to acquire  12,500  Glyko common  shares and
such option was exchanged for options to purchase  approximately 4,136 shares of
the Registrant's common stock.

     The Registrant's press release issued on August 22, 2002 is attached hereto
as Exhibit 99.1 and incorporated herein by reference.


Item 7.  Financial Statements, Pro Forma Financial Statements and Exhibits.

         (a)      Financial Statements of Business Acquired.

                  The financial information required by this Item 7(a) has not
been included with this filing and will be filed by amendment to this Form 8-K
not later than 60 days after the date this initial report on Form 8-K must be
filed.

         (b)      Pro Forma Financial Information.

                  The pro forma financial information required by this Item 7(b)
has not been included with this filing and will be filed by amendment to this
Form 8-K not later than 60 days after the date this initial report on Form 8-K
must be filed.



         (c)      Exhibits.

                  2.1     Acquisition Agreement for a Plan of Arrangement,
                          dated as of February 6, 2002, among BioMarin
                          Pharmaceutical Inc., BioMarin Acquisition (Nova
                          Scotia) Company, and Glyko Biomedical Ltd.,
                          previously filed on April 1, 2002 as Exhibit 2.5 to
                          the Registrant's Form 10-K, which is incorporated
                          herein by reference.

                  2.2     Amending Agreement, dated as of May 16, 2002, among
                          BioMarin Pharmaceutical Inc., BioMarin Acquisition
                          (Nova Scotia) Company and Glyko Biomedical Ltd.

                  99.1    Press Release of the Registrant dated August 22, 2002.







                                    SIGNATURE

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                        BioMarin Pharmaceutical Inc.,
                                        a Delaware corporation


Date: August 23, 2002                  By: /s/ Louis Drapeau
                                           -----------------------------------
                                           Louis Drapeau
                                           Chief Financial Officer and Secretary



                                  EXHIBIT INDEX

Exhibit No.                Description

2.1                       Acquisition Agreement for a Plan of Arrangement,
                          dated as of February 6, 2002, among BioMarin
                          Pharmaceutical Inc., BioMarin Acquisition (Nova
                          Scotia) Company, and Glyko Biomedical Ltd.,
                          previously filed on April 1, 2002 as Exhibit 2.5 to
                          the Registrant's Form 10-K, which is incorporated
                          herein by reference.

2.2                       Amending Agreement, dated as of May 16, 2002, among
                          BioMarin Pharmaceutical Inc., BioMarin Acquisition
                          (Nova Scotia) Company and Glyko Biomedical Ltd.

99.1                      Press Release of the Registrant dated August 22, 2002.