Rule 424(b)(2) Prospectus Supplement
                                                      Registration No. 333-48800


PROSPECTUS SUPPLEMENT NO. 1
TO PROSPECTUS DATED January 29, 2001


                                 101,523 Shares

                          BioMarin Pharmaceutical Inc.

                                  Common Stock

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     This  Prospectus  Supplement  supplements  information  contained  in  that
certain  Prospectus  of  BioMarin  Pharmaceutical  Inc.  dated  January 29, 2001
relating to the potential sale and issuance from time to time of up to 4,000,000
shares of BioMarin  common  stock.  This  Prospectus  Supplement is not complete
without,  and may not be delivered or utilized  except in connection  with,  the
Prospectus,  including any amendments or supplements  thereto.  This  Prospectus
Supplement is  incorporated  by reference into the  Prospectus.  You should read
this Prospectus Supplement and the accompanying  Prospectus carefully before you
invest.  Both documents contain information you should consider carefully before
making your investment decision.

     See "Risk  Factors"  beginning  on page 3 of the  Prospectus  to read about
risks that you should consider before buying shares of our common stock.

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     You  should  rely  only on the  information  provided  or  incorporated  by
reference  in this  Prospectus  Supplement  and  the  Prospectus.  We  have  not
authorized anyone else to provide you with different information. You should not
assume that the information in this Prospectus  Supplement is accurate as of any
date other than the date on the front of this Prospectus Supplement.

                           --------------------------

     NEITHER  THE  SECURITIES  EXCHANGE  COMMISSION  NOR  ANY  STATE  SECURITIES
COMMISSION  HAS APPROVED OR  DISAPPROVED  OF THE  SECURITIES  OR PASSED UPON THE
ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.

                           --------------------------

           The date of this Prospectus Supplement is January 31, 2001





                                TABLE OF CONTENTS

PROSPECTUS SUPPLEMENT

Plan of Distribution.........................................................S-1

PROSPECTUS

Summary........................................................................1

The Offering...................................................................2

Risk Factors...................................................................3

Forward Looking Statements....................................................14

Material Changes to our Company...............................................15

Use of Proceeds...............................................................16

Plan of Distribution..........................................................17

Legal Matters.................................................................18

Experts.......................................................................18









         The following information  supplements the information set forth in the
Prospectus.

                              PLAN OF DISTRIBUTION

         On  February  1,  2001,  we will issue and sell  101,523  shares of our
common stock to Acqua Wellington North American  Equities Fund, Ltd. pursuant to
this prospectus  supplement.  The common stock will be purchased at a negotiated
purchase price of $9.85. The purchase price reflects the volume weighted average
of the  trading  prices  of our  common  stock  on the  Nasdaq  National  Market
calculated  on January 25, 2001,  less a discount of 6% pursuant to the terms of
the common stock purchase agreement entered into between Acqua Wellington and us
on January 26, 2001. We will not pay any other  compensation in conjunction with
the sale of  these  shares  of our  common  stock.  See  "Plan of  Distribution"
beginning on page 17 of the prospectus.